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Safety Information

E1055

Sigma-Aldrich

Epichlorohydrin

99%

Synonym(s):

(±)-Epichlorohydrin, (±)-2-(Chloromethyl)oxirane, 1-Chloro-2,3-epoxypropane

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About This Item

Empirical Formula (Hill Notation):
C3H5ClO
CAS Number:
Molecular Weight:
92.52
Beilstein:
79785
EC Number:
MDL number:
UNSPSC Code:
12352100
PubChem Substance ID:

vapor density

3.2 (vs air)

vapor pressure

13.8 mmHg ( 21.1 °C)

Assay

99%

autoignition temp.

779 °F

expl. lim.

21 %

refractive index

n20/D 1.438 (lit.)

bp

115-117 °C (lit.)

mp

−57 °C (lit.)

density

1.183 g/mL at 25 °C (lit.)

SMILES string

ClCC1CO1

InChI

1S/C3H5ClO/c4-1-3-2-5-3/h3H,1-2H2

InChI key

BRLQWZUYTZBJKN-UHFFFAOYSA-N

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Signal Word

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Carc. 1B - Eye Dam. 1 - Flam. Liq. 3 - Repr. 2 - Skin Corr. 1B - Skin Sens. 1

Storage Class Code

3 - Flammable liquids

WGK

WGK 3

Flash Point(F)

82.4 °F

Flash Point(C)

28 °C

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

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Karnkamol Trisopon et al.
Pharmaceutics, 12(6) (2020-06-11)
A new co-processed, rice starch-based excipient (CS) was developed via a spray-drying technique. Native rice starch (RS) was suspended in aqueous solutions of 10%-15% cross-linked carboxymethyl rice starch (CCMS) and 0.5%-6.75% silicon dioxide (in the form of sodium silicate), before
An evaluation of the genetic toxicity of epichlorohydrin. A report of an expert group of the International Commission for Protection against Environmental Mutagens and Carcinogens.
R J Srám et al.
Mutation research, 87(3), 299-319 (1981-11-01)
Swetha Inturi et al.
ACS nano, 9(11), 10758-10768 (2015-10-22)
Notwithstanding rapid advances of nanotechnology in diagnostic imaging and drug delivery, the engineered nanocarriers still exhibit substantial lack of hemocompatibility. Thus, when injected systemically, nanoparticles are avidly recognized by blood leukocytes and platelets, but the mechanisms of immune recognition are
M Cirri et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 80(1), 46-53 (2011-08-16)
A new delivery system based on drug cyclodextrin (Cd) complexation and loading into nanostructured lipid carriers (NLC) has been developed to improve ketoprofen therapeutic efficacy. The proposed strategy exploits both the solubilizing and stabilizing properties of Cds and the prolonged
Epihalohydrins in organic synthesis.
Girija S Singh et al.
Chemical reviews, 113(3), 1441-1498 (2012-12-06)

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