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Safety Information

E004

Sigma-Aldrich

3-Hydroxymethyl-β-carboline

Synonym(s):

3-HMC

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About This Item

Empirical Formula (Hill Notation):
C12H10N2O
CAS Number:
65474-79-5
Molecular Weight:
198.22
MDL number:
MFCD00055074
UNSPSC Code:
12352100
PubChem Substance ID:
329798936
NACRES:
NA.22

form

solid

Quality Level

200

mp

215-219 °C

SMILES string

OCc1cc2c(cn1)[nH]c3ccccc23

InChI

1S/C12H10N2O/c15-7-8-5-10-9-3-1-2-4-11(9)14-12(10)6-13-8/h1-6,14-15H,7H2

InChI key

CPBYHTDUBNSBQM-UHFFFAOYSA-N

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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B Krespan et al.
Brain research, 295(2), 265-274 (1984-03-19)
The actions of the benzodiazepine (BDZ) antagonists 3-hydroxymethyl-beta-carboline (3-HMC), Ro 14-7437 and Ro 15-1788 were tested on single cell activity of rat hypothalamic neurons in tissue cultures and on membrane properties of CA1 hippocampal pyramidal neurons in transverse slices. In
R F Albrecht et al.
Neuropharmacology, 24(10), 957-963 (1985-10-01)
It has been reported that pentobarbital facilities binding to benzodiazepine receptors binding at anesthetic concentrations and that this action may play a role in the anesthetic potency of this barbiturate. The interaction between pentobarbital and benzodiazepine receptors was tested with
W E Hoffman et al.
European journal of pharmacology, 106(3), 585-591 (1984-11-27)
There is a need in clinical practice for an antagonist which can reverse the sedative action of benzodiazepines. Recently, 3-hydroxymethyl-beta-carboline (3-HMC) has been reported to inhibit the sleep inducing effects of flurazepam. The effects of flurazepam (0.5, 5 and 50
N Naughton et al.
Life sciences, 36(23), 2239-2245 (1985-06-10)
It is reported that benzodiazepines such as diazepam will stimulate the opiate receptor system and that B-carboline drugs, which are benzodiazepine antagonists, may interact with opiate receptors directly. The ability of 3-hydroxymethyl-B-carboline (3-HMC) to antagonize several parameters of fentanyl anesthesia
3-hydroxymethyl-beta-carboline antagonizes some pharmacologic actions of diazepam.
P Skolinick et al.
European journal of pharmacology, 69(4), 525-527 (1981-02-19)
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