D80800
N,N′-Dicyclohexylurea
98%
Synonym(s):
1,3-Dicyclohexylurea
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About This Item
Linear Formula:
C6H11NHCONHC6H11
CAS Number:
Molecular Weight:
224.34
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352100
EC Number:
219-213-7
MDL number:
Assay:
98%
Form:
solid
InChI key
ADFXKUOMJKEIND-UHFFFAOYSA-N
InChI
1S/C13H24N2O/c16-13(14-11-7-3-1-4-8-11)15-12-9-5-2-6-10-12/h11-12H,1-10H2,(H2,14,15,16)
SMILES string
O=C(NC1CCCCC1)NC2CCCCC2
assay
98%
form
solid
mp
232-233 °C (lit.)
Quality Level
Gene Information
human ... EPHX2(2053)
mouse ... Ephx2(13850)
Related Categories
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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Sarbani Ghosh et al.
Basic & clinical pharmacology & toxicology, 102(5), 453-458 (2008-03-04)
Cytochrome P450-derived epoxyeicosatrienoic acids (EET) are biologically active metabolites of arachidonic acid that have potent effects on renal vascular reactivity and tubular ion transport and have been implicated in the control of blood pressure. EETs are hydrolyzed to their less
Michele Aresta et al.
Dalton transactions (Cambridge, England : 2003), 39(30), 6985-6992 (2010-06-15)
NbCl(5) x (N,N'-dicyclohexylurea) 1a owns a distorted octahedral structure due to intramolecular NH...Cl bonding. The unit cell contains four units which are intermolecularly NH...Cl and NH...N bonded. An extended intramolecular network of H-bonding (N-H...Cl, CH...Cl, CH...N) causes the 3D self
T Watanabe et al.
Analytical biochemistry, 299(2), 227-234 (2001-12-04)
A rapid and reliable electrospray tandem mass spectrometric method for soluble epoxide hydrolase (sEH) inhibitors in rat hepatic microsomes is described. Four synthesized sEH inhibitors were extracted from rat hepatic microsomes with ethyl acetate and were determined by HPLC using
Xiang Fang et al.
American journal of physiology. Heart and circulatory physiology, 290(1), H55-H63 (2005-08-23)
Epoxyeicosatrienoic acids (EETs), lipid mediators synthesized from arachidonic acid by cytochrome P-450 epoxygenases, are converted by soluble epoxide hydrolase (SEH) to the corresponding dihydroxyeicosatrienoic acids (DHETs). Originally considered as inactive degradation products of EETs, DHETs have biological activity in some
Stevan Pecic et al.
Bioorganic & medicinal chemistry letters, 22(1), 601-605 (2011-11-15)
Inhibition of soluble epoxide hydrolase (sEH) has been proposed as a new pharmaceutical approach for treating hypertension and vascular inflammation. The most potent sEH inhibitors reported in literature to date are urea derivatives. However, these compounds have limited pharmacokinetic profiles.
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