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Safety Information

D67200

Sigma-Aldrich

2,3-Dichloro-1,4-naphthoquinone

98%

Synonym(s):

Dichlon

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About This Item

Empirical Formula (Hill Notation):
C10H4Cl2O2
CAS Number:
117-80-6
Molecular Weight:
227.04
Beilstein:
1073511
EC Number:
204-210-5
MDL number:
MFCD00001677
UNSPSC Code:
12352100
PubChem Substance ID:
24894043
NACRES:
NA.22

Assay

98%

form

powder

mp

194-197 °C (lit.)

SMILES string

ClC1=C(Cl)C(=O)c2ccccc2C1=O

InChI

1S/C10H4Cl2O2/c11-7-8(12)10(14)6-4-2-1-3-5(6)9(7)13/h1-4H

InChI key

SVPKNMBRVBMTLB-UHFFFAOYSA-N

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Pictograms

Skull and crossbonesEnvironment
GHS06,GHS09

Signal Word

Danger

Hazard Statements

H301,H315,H319,H410

Hazard Classifications

Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2 - Skin Irrit. 2

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

农药列管产品
危险化学品

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Certificates of Analysis (COA)

Lot/Batch Number
MKCC4556
BCBL6447V
BCBL9756V
BCBB5116
BCBB5116V

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C A Pritsos et al.
Biochemical pharmacology, 35(7), 1131-1135 (1986-04-01)
Dietary exposure of rats to a high concentration of 2,3-dichloro-1,4-naphthoquinone (CNQ) (2 g/kg diet) for 60 days altered cardiac mitochondrial function and activities of anti-oxidant enzymes in hepatic and cardiac tissue. CNQ moderately depressed the cardiac mitochondrial respiratory control ratio
C A Pritsos et al.
Biochemical pharmacology, 33(23), 3771-3777 (1984-12-01)
The addition of 2,3-dichloro-1,4-naphthoquinone (CNQ) to substrate-depleted, GSH-supplemented rat liver mitochondria resulted in a dose-dependent depletion of reactable suflhydryl groups and a concomitant increase in mitochondrial disulfide content at a ratio of 2 thiols depleted/disulfide generated. The molar ratio of
C A Pritsos et al.
Research communications in chemical pathology and pharmacology, 42(2), 271-280 (1983-11-01)
The addition of 2,3-dichloro-1,4-naphthoquinone (CNQ) to isolated mitochondria supplemented with GSSG resulted in a respiratory burst with the production of O2- and H2O2, and a decrease in the level of measurable disulfide. Superoxide generated by the xanthine oxidase system or
Ibrahim A Darwish
Journal of AOAC International, 88(1), 38-45 (2005-03-12)
Three simple and sensitive spectrophotometric methods were developed and validated for determination of the hydrochloride salts of fluoxetine, sertraline, and paroxetine in their pharmaceutical dosage forms. These methods were based on the reaction of the N-alkylvinylamine formed from the interaction
Christophe Morisseau et al.
Environmental health perspectives, 117(12), 1867-1872 (2010-01-06)
Legislation at state, federal, and international levels is requiring rapid evaluation of the toxicity of numerous chemicals. Whole-animal toxicologic studies cannot yield the necessary throughput in a cost-effective fashion, leading to a critical need for a faster and more cost-effective
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