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C91492

Sigma-Aldrich

Cyanogen bromide

reagent grade, 97%

Synonym(s):

Bromine cyanide

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About This Item

Linear Formula:
BrCN
CAS Number:
506-68-3
Molecular Weight:
105.92
Beilstein:
1697296
EC Number:
208-051-2
MDL number:
MFCD00011597
UNSPSC Code:
12352100
PubChem Substance ID:
57654055
NACRES:
NA.22

grade

reagent grade

Quality Level

200

vapor density

3.65 (vs air)

vapor pressure

100 mmHg ( 22.6 °C)

Assay

97%

form

crystals

bp

61-62 °C (lit.)

mp

50-53 °C (lit.)

storage temp.

2-8°C

SMILES string

BrC#N

InChI

1S/CBrN/c2-1-3

InChI key

ATDGTVJJHBUTRL-UHFFFAOYSA-N

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General description

Cyanogen bromide (CNBr) is a halogen halide. Its utility as a condensing agent during chemical ligation of oligodeoxyribonucleotides has been reported. Its threshold photoelectron (TPE) spectrum has been recorded under high resolution. The cryopolymerization of CNBr on irradiation has been investigated.

Application

Cyanogen bromide may be used:
  • To activate polysaccharides for coupling with erythrocytes.
  • As an oxidizing agent in urine thaimine assay.
  • In the preparation of 2-amino-5-(2′-thienyl)-1,3,4-oxadiazole.
For peptide cleavage and use in protein immobilization procedures. Reaction with C60Ph5Cl produces a novel phenylated isoquinolino[3′,4′:1,2][60]fullerene.

Signal Word

Danger

Hazard Classifications

Acute Tox. 2 Dermal - Acute Tox. 2 Inhalation - Acute Tox. 2 Oral - Aquatic Acute 1 - Eye Dam. 1 - Skin Corr. 1B

Supplementary Hazards

EUH032

WGK

WGK 3

Flash Point(F)

closed cup

Flash Point(C)

closed cup

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

危险化学品

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Applied Biochemistry and Biotechnology, 44, 135-135 (1994)
Org. Mass Spectrom., 28, 1395-1395 (1993)
Abdul-Sada, A.K. et al.
Chemical Communications (Cambridge, England), 307-307 (1998)
Threshold photoelectron spectroscopy of cyanogen bromide.
Yencha AJ, et al.
Chemical Physics Letters, 392(1), 202-208 (2004)
N I Sokolova et al.
FEBS letters, 232(1), 153-155 (1988-05-09)
Cyanogen bromide was found to condense oligodeoxyribonucleotides on a complementary template in aqueous solution. Optimum conditions for this vigorous and effective reaction were developed. CNBr proved to be useful for incorporation of phosphoramidate or pyrophosphate internucleotide bonds in DNA duplexes.
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