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Safety Information

B8154

Sigma-Aldrich

Baccatin III

≥95% (HPLC)

Synonym(s):

O-De[(2R,3S)-3-(Benzoylamino)-2-hydroxy-3-phenylpropanoyl]paclitaxel

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About This Item

Empirical Formula (Hill Notation):
C31H38O11
CAS Number:
27548-93-2
Molecular Weight:
586.63
MDL number:
MFCD00153921
UNSPSC Code:
12352005
PubChem Substance ID:
57653960
NACRES:
NA.22

Quality Level

100

Assay

≥95% (HPLC)

form

powder

storage temp.

2-8°C

SMILES string

CC(=O)O[C@H]1C(=O)[C@]2(C)[C@@H](O)C[C@H]3OC[C@@]3(OC(C)=O)[C@H]2[C@H](OC(=O)c4ccccc4)[C@]5(O)C[C@H](O)C(C)=C1C5(C)C

InChI

1S/C31H38O11/c1-15-19(34)13-31(38)26(41-27(37)18-10-8-7-9-11-18)24-29(6,20(35)12-21-30(24,14-39-21)42-17(3)33)25(36)23(40-16(2)32)22(15)28(31,4)5/h7-11,19-21,23-24,26,34-35,38H,12-14H2,1-6H3/t19-,20-,21+,23+,24-,26-,29+,30-,31+/m0/s1

InChI key

OVMSOCFBDVBLFW-VHLOTGQHSA-N

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Related Categories

Application

Precursor to paclitaxel

Pictograms

Health hazardExclamation mark
GHS08,GHS07

Signal Word

Danger

Hazard Statements

H315,H319,H335,H340,H350

Hazard Classifications

Carc. 1B - Eye Irrit. 2 - Muta. 1B - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

监管及禁止进口产品

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Certificates of Analysis (COA)

Lot/Batch Number
MKCP2901
MKBT4428V
098H1127
098H0559
078H0511

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Young-Hee Lee et al.
International immunopharmacology, 21(2), 487-493 (2014-06-25)
Myeloid-derived suppressor cells (MDSCs) mediate tumor-associated immune suppression in both cancer patients and tumor-bearing animals. Reduction or elimination of MDSCs reduces the rate of tumor progression and improves cancer therapies that employ mechanisms of immunity. Here we show that baccatin
Mohammad K Parvez et al.
Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society, 27(3), 389-400 (2019-04-13)
Despite high anti-HBV efficacies, while the nucleoside analogs (e.g., lamivudine) lead to the emergence of drug-resistance, interferons (e.g., IFN-α causes adverse side-effects. Comparatively, various natural or plant products have shown similar or even better efficacy. Hence, new antiviral strategies must
Xin Che et al.
Journal of pharmaceutical and biomedical analysis, 55(5), 1190-1196 (2011-05-03)
The isolation and characterization of the process related impurities and degradation products of larotaxel drug substance were described. Forced degradation of larotaxel was carried out under acidic, basic, oxidation, light and thermal conditions to assess the nature of the impurities.
M Onrubia et al.
Plant science : an international journal of experimental plant biology, 181(3), 282-287 (2011-07-19)
Taxol and related taxane accumulation in plants is regulated by the expression of genes involved in their biosynthesis. Although the metabolic pathway leading to taxol has been almost completely elucidated, comparatively little is known about the rate-limiting steps and their
Bing-Juan Li et al.
Nature communications, 8, 15544-15544 (2017-05-19)
The natural concentration of the anticancer drug Taxol is about 0.02% in yew trees, whereas that of its analogue 7-β-xylosyl-10-deacetyltaxol is up to 0.5%. While this compound is not an intermediate in Taxol biosynthetic route, it can be converted into
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