B7149
Benzthiazide
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About This Item
Empirical Formula (Hill Notation):
C15H14ClN3O4S3
CAS Number:
Molecular Weight:
431.94
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352100
EC Number:
202-061-0
MDL number:
Form:
solid
InChI key
NDTSRXAMMQDVSW-UHFFFAOYSA-N
InChI
1S/C15H14ClN3O4S3/c16-11-6-12-14(7-13(11)25(17,20)21)26(22,23)19-15(18-12)9-24-8-10-4-2-1-3-5-10/h1-7H,8-9H2,(H,18,19)(H2,17,20,21)
SMILES string
NS(=O)(=O)c1cc2c(NC(CSCc3ccccc3)=NS2(=O)=O)cc1Cl
form
solid
Quality Level
Gene Information
human ... SLC12A3(6559)
Related Categories
signalword
Danger
hcodes
Hazard Classifications
Resp. Sens. 1 - Skin Sens. 1
Storage Class
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
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R A Adler et al.
Metabolism: clinical and experimental, 35(7), 668-672 (1986-07-01)
There is evidence that prolactin (PRL) excess plays a role in the etiology of osteoporosis associated with human prolactinoma. Calcium balance in human hyperprolactinemia has not been thoroughly investigated. In the present study, rats with excess circulating PRL levels (male
M C Meyer et al.
Biopharmaceutics & drug disposition, 3(1), 1-9 (1982-01-01)
An assay was developed for benzthiazide in plasma, urine and feces, using high performance liquid chromatography (HPLC). A reverse-phase column was employed, with quantitation af 280 nm, using polythiazide as an internal standard. In three of four human subjects who
Thiazides XIII: Dissolution testing: a bioavailability predictor for benzthiazide tablets.
V P Shah et al.
Biopharmaceutics & drug disposition, 3(3), 283-285 (1982-07-01)
J P Huang et al.
Journal of analytical toxicology, 23(5), 337-342 (1999-09-17)
This study describes a matrix-assisted laser-desorption-ionization (MALDI) mass spectrometry for rapid screening of 12 diuretics in spiked urine. C60 is used as the matrix for MALDI. Diuretics are directly analyzed by C60-MALDI without previous derivatization. The fact that most diuretic
Hee Sook Lee et al.
BMC systems biology, 6, 80-80 (2012-07-04)
The process of drug discovery and development is time-consuming and costly, and the probability of success is low. Therefore, there is rising interest in repositioning existing drugs for new medical indications. When successful, this process reduces the risk of failure
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