Skip to Content
Merck
CN
All Photos(1)

Documents

Safety Information

ALD00508

Sigma-Aldrich

Yu Fluorination Ligand

≥95%

Sign Into View Organizational & Contract Pricing
All Photos(1)
Synonym(s):
2,5,6,8-tetramethyl-3,4-dihydro-2H-pyrano[2,3-b]quinoline
Empirical Formula (Hill Notation):
C16H19NO
CAS Number:
1771764-64-7
Molecular Weight:
241.33
UNSPSC Code:
41116155
PubChem Substance ID:
329772697
NACRES:
NA.22

Quality Level

100

Assay

≥95%

form

powder

reaction suitability

reagent type: catalyst
reagent type: ligand
reaction type: C-H Activation

SMILES string

CC1=C2C(OC(C)CC2)=NC3=C1C(C)=CC(C)=C3

InChI

1S/C16H19NO/c1-9-7-10(2)15-12(4)13-6-5-11(3)18-16(13)17-14(15)8-9/h7-8,11H,5-6H2,1-4H3

InChI key

LOKRNFHHPZEJLL-UHFFFAOYSA-N

Related Categories

General description

Yu Fluorination Ligand is widely employed for the chemoselective functionalization of sp2- and sp3 C-H bonds.

Application

The Yu Fluorination Ligand in tandem with Selectfluor(R) (Aldrich 439479) under palladium catalysis can promote direct fluorination of C(sp3)-H bonds stereoselectively. Yu and coworkers have displayed this on amino acid derivatives with directing group assistance from the Yu-Wasa Auxiliary (Aldrich 791806).

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

新产品

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Related Content

Yu Group – Professor Product Portal

The Yu program centers around the discovery of catalytic carbon–carbon and carbon–heteroatom bond forming reactions based on C–H activation. Target transformations are selected to enable 1) the use of simple and abundant starting materials such as aliphatic acids, amines and alcohols, and 2) disconnections that drastically shorten the synthesis of a drug molecule or a major class of biologically active compounds.

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service