A56655
4-Amino-3-hydroxybutyric acid
98%
Synonym(s):
DL-γ-Amino-β-hydroxybutyric acid
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About This Item
Linear Formula:
H2NCH2CH(OH)CH2CO2H
CAS Number:
Molecular Weight:
119.12
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352106
EC Number:
213-106-9
MDL number:
InChI key
YQGDEPYYFWUPGO-UHFFFAOYSA-N
InChI
1S/C4H9NO3/c5-2-3(6)1-4(7)8/h3,6H,1-2,5H2,(H,7,8)
SMILES string
NCC(O)CC(O)=O
assay
98%
form
powder or crystals
reaction suitability
reaction type: solution phase peptide synthesis
color
white to yellow
mp
223 °C (dec.) (lit.)
application(s)
peptide synthesis
Quality Level
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
Storage Class
11 - Combustible Solids
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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T W Stone
European journal of pharmacology, 128(1-2), 81-83 (1986-08-22)
Kynurenine and kynurenic acid are known to produce convulsions in rats and mice and it has been reported that kynurenine can displace GABA from its neuronal binding sites. The present study shows that neither kynurenine nor kynurenic acid are antagonist
[Neurochemical aspects of the pharmacology of GABAergic substances].
K S Raevskiĭ
Farmakologiia i toksikologiia, 44(5), 517-529 (1981-09-01)
D Jordan et al.
Brain research, 268(1), 105-110 (1983-05-23)
Various doses of GABA from 0.25 to 5 mumol injected into the third ventricle decrease serum TSH rapidly. The same effect was observed with GABOB (10 mumol), the hydroxylated form of GABA. The inhibitory effect of both of these drugs
M Candela et al.
Journal of chromatography. A, 890(2), 273-280 (2000-09-29)
A rapid and simple reversed-phase liquid chromatographic method that did not require the derivatization of 4-amino-3-hydroxybutyric acid (GABOB) was developed and validated. The method proved to be suitable for the determination of GABOB concentrations in finished pharmaceutical product (tablets). The
T Noto et al.
Journal of neurochemistry, 51(2), 548-551 (1988-08-01)
gamma-Amino-beta-[3H]hydroxybutyric acid ([3H]-GABOB) was formed in rat brain from 2-[3H]-hydroxyputrescine that had been chemically synthesized from 2-oxoputrescine and [3H]sodium borohydride. After the injection of 2-[3H]hydroxyputrescine into the lateral ventricle of a rat brain, the rat was killed and then the
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