A47052
6-Aminochrysene
95%
Synonym(s):
6-Chrysenamine
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About This Item
Empirical Formula (Hill Notation):
C18H13N
CAS Number:
Molecular Weight:
243.30
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352100
EC Number:
220-149-7
MDL number:
Product Name
6-Aminochrysene, 95%
InChI key
KIVUHCNVDWYUNP-UHFFFAOYSA-N
InChI
1S/C18H13N/c19-18-11-17-13-6-2-1-5-12(13)9-10-15(17)14-7-3-4-8-16(14)18/h1-11H,19H2
SMILES string
Nc1cc2c3ccccc3ccc2c4ccccc14
assay
95%
form
solid
mp
209-211 °C (lit.)
Quality Level
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Related Categories
Application
Produces tumors in mice.
signalword
Warning
hcodes
pcodes
Hazard Classifications
Acute Tox. 4 Oral
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
Regulatory Information
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H Yamazaki et al.
Carcinogenesis, 15(3), 465-470 (1994-03-01)
In order to address the hypothesis that 6-aminochrysene (6-AC) is converted to genotoxic products by cytochrome P450 enzymes via two activation pathways (N-hydroxylation and epoxidation), the activation of 6-AC and trans-1,2-dihydro-1,2-dihydroxy-6-aminochrysene (6-AC-diol) to genotoxic metabolites was examined in rat and
M Mimura et al.
Drug metabolism and disposition: the biological fate of chemicals, 21(6), 1048-1056 (1993-11-01)
A cytochrome P-450 (P-450) enzyme of the CYP2B subfamily was partially purified from human liver microsomes and characterized with respect to immunochemical properties, N-terminal amino acid sequence, and catalytic activities toward typical P-450 substrates. P-450 enzymes were monitored in chromatographic
K B Delclos et al.
Carcinogenesis, 8(11), 1703-1709 (1987-11-01)
Since 6-nitrochrysene and 6-aminochrysene have shown activity in carcinogenicity bioassays, we have begun an investigation of their metabolic activation pathways and the nature of the carcinogen-DNA adducts that may be formed. N-Hydroxy-6-aminochrysene (N-hydroxy-AC), a candidate proximate or ultimate carcinogen and
K B Delclos et al.
IARC scientific publications, (124)(124), 79-86 (1993-01-01)
Carcinogenic arylamines and nitroaromatic hydrocarbons are chemicals that present occupational health hazards and share pathways of metabolic activation. The 32P-postlabelled DNA adducts formed in Chinese hamster ovary (CHO) cells treated with metabolites from two pathways that are common to the
B G Lake et al.
Toxicology and applied pharmacology, 138(2), 231-241 (1996-06-01)
Precision-cut liver slices were prepared from male Sprague-Dawley rats (pretreated with or without Aroclor 1254), male Dunkin-Hartley guinea pigs, male cynomolgus monkeys, and humans. Liver slices were cultured for 24 hr using a dynamic organ culture system in medium containing
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