945781
Methoxy-poly(ethylene glycol) amine-block-poly-L-lysine hydrobromide
Mn 5000 (mPEG), Mn 15000 (PLL)
Synonym(s):
mPEG-amine5k-PLL15k, mPEGNH2-PLL
SMILES string
COCCOCCNC(C(CCCC[NH3+])N[H])=O.[Br-]
form
powder or chunks
mol wt
Mn 15000 (PLL), Mn 5000 (mPEG)
color
white
application(s)
(Drug Delivery)
storage temp.
−20°C
Quality Level
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General description
Methoxy poly(ethylene glycol) amine-block-poly(L-lysine) (mPEG-PLL) is a cationic diblock copolymer consiting of amine-functionalized PEG and PLL that can be used in drug delivery applications. The cationic PLL block can bind to DNA or RNA, as well as other therapuetic agents, while the amine-functionalized PEG block can be further functionalized with targeting moieties for targeted and controlled drug delivery. This cationic diblock copolymer can self-assemble in the presence of a drug to form polymeric micelles and polymersomes.
Application
- Non-viral gene delivery application
- Targeted drug delivery application
- Protein coatings and tissue culture
Features and Benefits
- Self-assemble capability to form micelles and polymersomes
- Amine functional group at the side chain enables further rapid functionalization
- Cationic poly(L-lysine) has excellent DNA and RNA condensation property
- Biodegradable, biocompatible and water soluble
Storage Class
11 - Combustible Solids
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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