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Merck
CN

943401

1-(6-Bromo-1-methylindazol-3-yl)hexahydropyrimidine-2,4-dione

new

≥95%

Synonym(s):

(6-Bromo-1-methylindazol-3-yl)-1,3-diazinan-2,4-dione, 1-(6-Bromo-1-methyl-1H-indazol-3-yl)dihydro-2,4(1H,3H)-pyrimidinedione, 1-(6-Bromo-1-methylindazol-3-yl)-1,3-diazinane-2,4-dione, 2,4(1H,3H)-Pyrimidinedione, 1-(6-bromo-1-methyl-1H-indazol-3-yl)dihydro-

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About This Item

Empirical Formula (Hill Notation):
C12H11BrN4O2
CAS Number:
2446913-88-6
Molecular Weight:
323.15
MDL number:
MFCD35084702

Key Documents

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description

Reaction suitability: A functionalized CRBN ligand for development of small molecule degraders

Quality Level

100

Assay

≥95%

form

amorphous solid

color

pale yellow to beige

functional group

(Bromide functionality for incorporating linker)

storage temp.

2-8°C

SMILES string

O=C1NC(CCN1C2=NN(C)C3=C2C=CC(Br)=C3)=O

InChI

InChI=1S/C12H11BrN4O2/c1-16-9-6-7(13)2-3-8(9)11(15-16)17-5-4-10(18)14-12(17)19/h2-3,6H,4-5H2,1H3,(H,14,18,19)

InChI key

FVEJZRXMQPIZQZ-UHFFFAOYSA-N

General description

This compound is a dihydropyrimidine-dione derivative, featuring an indazole ring substituted with a bromine and a methyl group, linked to a dihydropyrimidinedione moiety.

Application

A functionalized CRBN ligand for synthesis of small molecule degraders.

Features and Benefits

Bromide functionality is useful for incorporating linker for choice for degrader diversity.

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
0000499490
0000499490

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Small-Molecule PROTACS: New Approaches to Protein Degradation
Toure M,et.al
Angewandte Chemie (International ed. in English), 55, 1966-1973 (2016)
Targeted Protein Degradation by Small Molecules
Bondeson DP,et.al
Annual Review of Pharmacology and Toxicology, 57, 107-123 (2017)
Targeted Protein Degradation: from Chemical Biology to Drug Discovery
Cromm PM,et.al
Cell Chemical Biology (2017)

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