937819
Methoxy-poly(ethylene glycol) amine-block-poly-L-lysine hydrobromide
PEG average Mn 2000, PLLA average Mn 5000
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Synonym(s):
Block copolymer, Drug delivery polymer, Polymeric micelles, Tissue engineering, Tumor imaging, mPEG-amine2k -PLL5k, mPEGNH2-PLL (Hidden synonyms: Polymeric micelles, Block copolymer, Tumor imaging, Tissue engineering, Drug delivery polymer)
Linear Formula:
C3H9NO(OC2H4)x-(C6H13N2OBr)n
UNSPSC Code:
12162002
NACRES:
NA.21
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form
chunks
Quality Level
mol wt
PEG average Mn 2000
PLLA average Mn 5000
color
white
storage temp.
2-8°C
SMILES string
COCCOCCNC(C(CCCC[NH3+])N[H])=O.[Br-]
InChI
1S/C11H25N3O3.BrH/c1-16-8-9-17-7-6-14-11(15)10(13)4-2-3-5-12;/h10H,2-9,12-13H2,1H3,(H,14,15);1H
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General description
Methoxy poly(ethylene glycol) amine-block-poly(L-lysine) (mPEG-PLL) is a cationic diblock copolymer consisting of amine-functionalized PEG and PLL that can be used in drug delivery applications. The cationic PLL block can bind to DNA or RNA, as well as other therapuetic agents, while the amine-functionalized PEG block can be further functionalized with targeting moieties for targeted and controlled drug delivery. This cationic diblock copolymer can self-assemble in the presence of a drug to form polymeric micelles and polymersomes.
Application
*Non-viral gene delivery application
*Targeted drug delivery application
*Protein coatings and tissue culture
*Targeted drug delivery application
*Protein coatings and tissue culture
Features and Benefits
*Self-assemble capability to form micelles and polymersomes
*Amine functional group at the side chain enables further rapid functionalization
*Cationic poly(L-lysine) has excellent DNA and RNA condensation property
*Biodegradable, biocompatible and water soluble
*Amine functional group at the side chain enables further rapid functionalization
*Cationic poly(L-lysine) has excellent DNA and RNA condensation property
*Biodegradable, biocompatible and water soluble
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
新产品
Certificates of Analysis (COA)
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Find documentation for the products that you have recently purchased in the Document Library.
Poly(beta-amino ester)s as gene delivery vehicles: challenges and opportunities
Karlsson J, et al.
Expert Opinion on Drug Delivery, 17, 1395-1410 (2020)
Poly (??amino esters) based potential drug delivery and targeting polymer; an overview and perspectives (review)
Iqbal S, et al.
European Polymer Journal, 141, 110097-110097 (2020)
Qi Y Wang et al.
Journal of materials chemistry. B, 7(7), 1076-1086 (2019-02-21)
Copolymers as a kind of drug delivery carrier always lack targeting efficiency. So a peptide conjugated to a drug delivery system has attracted much attention for tumor-targeted nanomedicine. Thus, we here report a conjugation compound consisting of a copolymer (PEG-b-PLL)
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