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937177

Sigma-Aldrich

Methoxy-poly(ethylene glycol) amine-block-poly-L-lysine hydrobromide

PEG average Mn 2000, PLLA average Mn 10000

Synonym(s):

Block copolymer, Drug delivery polymer, Polymeric micelles, Tissue engineering, Tumor imaging, mPEG-amine2k -PLL10k, mPEGNH2-PLL

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About This Item

Linear Formula:
C3H9NO(OC2H4)x-(C6H13N2OBr)n
UNSPSC Code:
12162002
NACRES:
NA.21

form

powder or chunks

Quality Level

100

mol wt

PEG average Mn 2000
PLLA average Mn 10000

color

white to off-white

storage temp.

−20°C

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General description

Methoxy poly(ethylene glycol) amine-block-poly(L-lysine) (mPEG-PLL) is a cationic diblock copolymer consisting of amine-functionalized PEG and PLL that can be used in drug delivery applications to improve therapeutic efficacy. The cationic PLL block can bind to DNA or RNA, as well as other therapeutic agents, while the amine-functionalized PEG block inhibits protein adsorption and can be further functionalized with targeting moieties for targeted and controlled drug delivery. This cationic diblock copolymer can self-assemble in the presence of a drug to form polymeric micelles and polymersomes.

Application

  • Non-viral gene delivery applications
  • Targeted drug delivery applications
  • Protein coatings and tissue culture

Features and Benefits

  • Self-assemble capability to form micelles and polymersomes
  • Amine functional group at the side chain enables further rapid functionalization
  • Cationic poly(L-lysine) has excellent DNA and RNA condensation property
  • Biodegradable, biocompatible and water soluble

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

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Poly (??amino esters) based potential drug delivery and targeting polymer; an overview and perspectives (review)
Iqbal S, et al.
European Polymer Journal, 141, 110097-110097 (2020)
Poly(beta-amino ester)s as gene delivery vehicles: challenges and opportunities
Karlsson J, et al.
Expert Opinion on Drug Delivery, 17, 1395-1410 (2020)
Qi Y Wang et al.
Journal of materials chemistry. B, 7(7), 1076-1086 (2019-02-21)
Copolymers as a kind of drug delivery carrier always lack targeting efficiency. So a peptide conjugated to a drug delivery system has attracted much attention for tumor-targeted nanomedicine. Thus, we here report a conjugation compound consisting of a copolymer (PEG-b-PLL)

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