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936405

Sigma-Aldrich

Fmoc-Val-Cit-PAB-OH

≥95%

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Synonym(s):
N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-valyl-N5-(aminocarbonyl)-N-[4-(hydroxymethyl)phenyl]-L-ornithinamide, L-Ornithinamide, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-valyl-N5-(aminocarbonyl)-N-[4-(hydroxymethyl)phenyl]
Empirical Formula (Hill Notation):
C33H39N5O6
CAS Number:
159858-22-7
Molecular Weight:
601.69
MDL number:
MFCD22417106
UNSPSC Code:
12352116
NACRES:
NA.22

Quality Level

100

Assay

≥95%

form

solid

color

white to off-white

storage temp.

2-8°C

SMILES string

OCC(C=C1)=CC=C1NC([C@H](CCCNC(N)=O)NC([C@H](C(C)C)NC(OCC2C3=CC=CC=C3C4=CC=CC=C42)=O)=O)=O

InChI

InChI= 1S/C33H39N5O6/c1-20(2)29(38-33(43)44-19-27-25-10-5-3-8-23(25)24-9-4-6-11-26(24)27)31(41)37-28(12-7-17-35-32(34)42)30(40)36-22-15-13-21(18-39)14-16-22/h3-6,8-11,13-16,20,27-29,39H,7,12,17-19H2,1-2H3,(H,36,40)(H,37,41)(H,38,43)(H3,34,35,42)/t28-,29-/m0/s1

Application

This is a cathepsin cleavable linker used in the construction of antibody drug conjugates (ADC & Bioconjugation).

Other Notes

Bifunctional Cathepsin cleaveable linkers

ADC & Bioconjugation

Chemical Biology Tools

Impact of linker length on the activity of PROTACs

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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