All Photos(1)
Fmoc-Gly-Gly-OH, 2-[2-([[(9H-Fluoren-9-yl)methoxy]carbonyl]amino)acetamido]acetic acid, N-9-Fluorenylmethoxycarbonylglycylglycine, N-Fluorenylmethoxycarbonylglycylglycine, N-[(9H-Fluoren-9-ylmethoxy)carbonyl]glycylglycine (ACI), Glycine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]glycyl- (9CI, ACI), Glycine, N-[N-[(9H-fluoren-9-ylmethoxy)carbonyl]glycyl]- (ZCI)
C19H18N2O5
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Quality Level
Assay
≥95%
form
powder or crystals
color
white to off-white
storage temp.
2-8°C
SMILES string
O=C(OCC1C=2C=CC=CC2C=3C=CC=CC31)NCC(=O)NCC(=O)O
InChI
1S/C19H18N2O5/c22-17(20-10-18(23)24)9-21-19(25)26-11-16-14-7-3-1-5-12(14)13-6-2-4-8-15(13)16/h1-8,16H,9-11H2,(H,20,22)(H,21,25)(H,23,24)
Application
Fmoc-Gly-Gly-OH is a lysosomally cleavable linker used in construction of antibody-drug conjugates (ADC & Bioconjugation).
Other Notes
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
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Nature reviews. Drug discovery, 16(5), 315-337 (2017-03-18)
Antibody-drug conjugates (ADCs) are one of the fastest growing classes of oncology therapeutics. After half a century of research, the approvals of brentuximab vedotin (in 2011) and trastuzumab emtansine (in 2013) have paved the way for ongoing clinical trials that
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