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936111

Sigma-Aldrich

SerrKap Palladacycle

≥95%

Synonym(s):

[Pd(μ-AcO)(4-Cl-CˆN-SO3Na)]2

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About This Item

Empirical Formula (Hill Notation):
C30H22Cl2N2Na2O10Pd2S2
CAS Number:
Molecular Weight:
964.36
UNSPSC Code:
12352101
NACRES:
NA.21

Quality Level

Assay

≥95%

form

solid

color

yellow

storage temp.

−20°C

SMILES string

[H]C(C1=C([Pd]23oc(C)o[Pd]4(C5=C(C([H])=[N]4C6=CC=C(S(=O)(O[Na])=O)C=C6)C=CC(Cl)=C5)oc(C)o2)C=C(Cl)C=C1)=[N]3C7=CC=C(S(=O)(O[Na])=O)C=C7

Application

SerrKap Palladacycle is a phosphine-free, water soluble Pd dimer catalyst used extensively for low temperature modifications of nucleosides via Suzuki-Miyaura and Heck reactions. It is also compatible with flow reaction conditions and suitable for late-stage oligonucleotide and DNA modification.

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Hazard Statements

Precautionary Statements

Hazard Classifications

Aquatic Chronic 4

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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Santosh Kori et al.
Current protocols, 2(7), e502-e502 (2022-07-28)
Modification of nucleosides via cross-coupling processes has been carried out extensively on unprotected halonucleosides to produce functionalized nucleosides that are often developed for incorporation into oligonucleotides or used as fluorescent probes. This approach requires protection of the 5'-OH with the

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