935468
Aldehyde functionalized hyaluronic acid
Degree of functionalization ~40%
Synonym(s):
HA aldehyde, HA-A, Hyaluronic acid A. Oxidized Hyaluronic acid
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About This Item
Linear Formula:
(C14H20NNaO11)n(C14H18NNaO11)m
NACRES:
NA.28
UNSPSC Code:
12352201
Product Name
Aldehyde functionalized hyaluronic acid, Degree of functionalization ~40%
form
powder or chunks ( or fibers)
color
white to off-white
storage temp.
−20°C
Quality Level
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Application
HA is increasingly used for a many biomedical applications because it promotes cell migration, angiogenesis, cell viability, and proliferation. Aldehyde functionalized HA can be used to develop hydrogels for tissue engineering, regenerative medicing, bioprinting, and drug delivery applications.
Features and Benefits
- Coupling capabilities with primary amines
- Biocompatible functionalized natural polymer
- Promotes a variety of cellular and tissue functions
General description
Hyaluronic acid (HA) is an important component of the natural extracellular matrix which plays a vital role in various cellular and tissue functions. It represents some unique properties such as excellent gel-forming properties and chemical modification ability through hydroxyl and carboxyl groups that make them useful for tissue engineering applications. Aldehyde functionalized hyaluronic acid, or partially oxidized hyaluronic acid, contains two aldehyde groups in the repeating unit of HA. The dialdehyde groups are capable of reductive coupling with primary amines, providing a platform for a wide range of chemical modifications for a variety of applications.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Modified hyaluronic acid-based materials for biomedical applications
Tiwari S, et al.
International Journal of Biological Macromolecules, 121, 556-571 (2019)
Hyaluronic Acid and Controlled Release: A Review
Ilker S. Baye, et al.
Molecules (Basel), 25, 2649-2649 (2020)
General dialdehyde click chemistry for amine bioconjugation
Elahipanah S, et al.
Bioconjugate Chemistry, 28, 1422-1433 (2017)
Strategies for Hyaluronic Acid-Based Hydrogel Design in Drug Delivery
Trombino S, et al.
Pharmaceutics, 11, 407-407 (2019)
Oxi-HA/ADH Hydrogels: A Novel Approach in Tissue Engineering and Regenerative Medicine
Franca C G, et al.
Polysaccharides, 2, 477-496 (2021)
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