935468
Aldehyde functionalized hyaluronic acid
Degree of functionalization ~40%
Synonym(s):
HA aldehyde, HA-A, Hyaluronic acid A. Oxidized Hyaluronic acid
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About This Item
Linear Formula:
(C14H20NNaO11)n(C14H18NNaO11)m
UNSPSC Code:
12352201
NACRES:
NA.28
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General description
Hyaluronic acid (HA) is an important component of the natural extracellular matrix which plays a vital role in various cellular and tissue functions. It represents some unique properties such as excellent gel-forming properties and chemical modification ability through hydroxyl and carboxyl groups that make them useful for tissue engineering applications. Aldehyde functionalized hyaluronic acid, or partially oxidized hyaluronic acid, contains two aldehyde groups in the repeating unit of HA. The dialdehyde groups are capable of reductive coupling with primary amines, providing a platform for a wide range of chemical modifications for a variety of applications.
Application
HA is increasingly used for a many biomedical applications because it promotes cell migration, angiogenesis, cell viability, and proliferation. Aldehyde functionalized HA can be used to develop hydrogels for tissue engineering, regenerative medicing, bioprinting, and drug delivery applications.
Features and Benefits
- Coupling capabilities with primary amines
- Biocompatible functionalized natural polymer
- Promotes a variety of cellular and tissue functions
related product
Product No.
Description
Pricing
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
新产品
Certificates of Analysis (COA)
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Strategies for Hyaluronic Acid-Based Hydrogel Design in Drug Delivery
Trombino S, et al.
Pharmaceutics, 11, 407-407 (2019)
General dialdehyde click chemistry for amine bioconjugation
Elahipanah S, et al.
Bioconjugate Chemistry, 28, 1422-1433 (2017)
Hyaluronic Acid and Controlled Release: A Review
Ilker S. Baye, et al.
Molecules (Basel), 25, 2649-2649 (2020)
Oxi-HA/ADH Hydrogels: A Novel Approach in Tissue Engineering and Regenerative Medicine
Franca C G, et al.
Polysaccharides, 2, 477-496 (2021)
Modified hyaluronic acid-based materials for biomedical applications
Tiwari S, et al.
International Journal of Biological Macromolecules, 121, 556-571 (2019)
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