933899
N-(2-Hydroxy) propyl-3-trimethylammonium chitosan chloride
degree of quaternization 50%
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Synonym(s):
Chioisan, HTCC, Quaternized Chitosan, Solube chitosan, TMC, Trimethyl chitoan
Linear Formula:
(C12H25N2O5Cl)n(C8H13NO5)m
UNSPSC Code:
12352201
NACRES:
NA.21
Recommended Products
description
NMR: Conforms to structure
Quality Level
form
(solid, chunks or fiber)
color
white to off-white
storage temp.
2-8°C
Related Categories
General description
Chitosan offers remarkable biological properties; it has been widely used in drug delivery and tissue engineering applications. Chitosan has good mucoadhesive properties due to its positive charge, which increases the adhesion to mucosa and facilitates drug penetration. Also, chitosan possesses hemostatic properties, which makes it a good candidate for wound dressing applications.
The quaternization of the primary amine increases the water solubility of chitosan and keeps chitosan soluble over a wide pH range. Cationically modified chitosan such as N-(2-Hydroxy)propyl-3-trimethyl ammonium chitosan chloride (HTCC) also imparts excellent antibacterial activity and immuno-enhancing characteristics. HTCC also used in gene delivery applications
The quaternization of the primary amine increases the water solubility of chitosan and keeps chitosan soluble over a wide pH range. Cationically modified chitosan such as N-(2-Hydroxy)propyl-3-trimethyl ammonium chitosan chloride (HTCC) also imparts excellent antibacterial activity and immuno-enhancing characteristics. HTCC also used in gene delivery applications
Application
Small molecule and nucleic acid delivery
Tissue engineering
Antibacterial coatings
Tissue engineering
Antibacterial coatings
Features and Benefits
Water soluble
Cationically modified
Naturally derived and biocompatible
Cationically modified
Naturally derived and biocompatible
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
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Bo Xiao et al.
Colloids and surfaces. B, Biointerfaces, 91, 168-174 (2011-11-23)
A series of N-(2-hydroxy)propyl-3-trimethyl ammonium chitosan chloride (HTCC) samples with various degrees of quaternization ranging from 12.4 to 43.7% was synthesized. The structures and properties of HTCC were investigated by FT-IR, (1)H NMR, conductometric titration and XRD analysis. It was
Kai Zhao et al.
Vaccines, 9(9) (2021-09-29)
Porcine parvovirus (PPV) is the most important infectious agent causing infertility in pigs, which can be prevented by routine vaccination. Successful vaccination depends on the association with potent adjuvants that can enhance the immunogenicity of antigen and activate the immune
Hamid Hamedi et al.
Carbohydrate polymers, 199, 445-460 (2018-08-26)
Advanced development of chitosan hydrogels has led to new drug delivery systems that can release their active ingredients in response to environmental stimuli. This review considers more recent investigation of chitosan hydrogel preparations and the application of these preparations for
Microbiocidal activity of chitosan-N-2-hydroxypropyl trimethyl ammonium chloride
Chi W, et al.
Journal of Applied Polymer Science, 103, 3851-3856 (2007)
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