All Photos(1)
Synonym(s):
(2S)-2-{2-[(2,5-Dichlorophenyl)formamido]acetamido}-4-methylpentanoic acid, CANDDY_MLN Tag
Empirical Formula (Hill Notation):
C15H18Cl2N2O4
Recommended Products
Quality Level
Assay
≥95.0%
form
powder
storage temp.
2-8°C
SMILES string
ClC1=CC=C(Cl)C(C(NCC(N[C@H](C(O)=O)CC(C)C)=O)=O)=C1
Related Categories
Application
CANDDY (Chemical knockdown with Affinity aNd Degradation DYnamics) employs a bispecific molecule (target interactor + linker + CANDDY_MLN) that degrades protein by direct recruitment to the proteasome. Shown to selectively and dose-dependently degrade KRAS G12D/V and MDM2 proteins and suppress their signaling without non-specific cytotoxic effects.
CANDDY, a protein-slaying approach, occurs without ubiquitination and bypasses the need for an E3 ligase. Has the potential to overcome the current limitations of proteolysis and to expand the application scope of degraders.
CANDDY, a protein-slaying approach, occurs without ubiquitination and bypasses the need for an E3 ligase. Has the potential to overcome the current limitations of proteolysis and to expand the application scope of degraders.
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
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Certificates of Analysis (COA)
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