928925
Poly(ethylene glycol)-block-poly(2-(Dimethylamino)ethyl methacrylate)
quaternized, PEG average Mn 5,000, quaternized PDMAEMA Mn 18,000
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Synonym(s):
PEG-PQDMAEMA, Quaternized PEG-PDMAEMA
Linear Formula:
CH3(C2H4O)nC6H7O2N(C9H18O2NCl)mC7H5S2
UNSPSC Code:
51171641
NACRES:
NA.25
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General description
Poly(ethylene glycol)-block-Poly(2-(Dimethylamino)ethyl methacrylate) quaternized (PEG-b-PQDMAEMA) is a biocompatible block polyelectrolyte composed of a neutral PEG block and a cationic quaternized Poly(2-(Dimethylamino)ethyl methacrylate) (PDMAEMA) block. The PQDMAEMA carries quaternary ammonium salt moieties along the polymer chain.
Application
- Antimicrobial applications
- Non-viral gene delivery
PEG-b-PQDMAEMA is a versatile polymer with applications in antimicrobial applications and gene delivery. Due to its high efficacy in antimicrobial systems, it is an ideal candidate for the fabrication of long-lasting, contact-active bactericidal materials. PQDMAEMA is also a promising material for non-viral gene delivery. PEGylation of PQDMAEMA reduces cytotoxicity and increases gene delivery efficiency.
WGK
WGK 3
Regulatory Information
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Quaternized poly(2-(dimethylamino)ethyl methacrylate)-grafted agarose copolymers for multipurpose antibacterial applications
Xu LQ, et al.
Royal Society of Chemistry Advances, 5, 61742-61742 (2015)
Film Properties and Antimicrobial Efficacy of Quaternized PDMAEMA Brushes: Short vs Long Alkyl Chain Length
Koufakis E, et al.
Langmuir, 36, 3482-3482 (2020)
PDMAEMA based gene delivery materials
Agarwal S, et al
Materials Today, 15, 388-388 (2012)
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