Skip to Content
Merck
CN
All Photos(1)

Documents

926248

Sigma-Aldrich

Redox Responsive Poly(ethylene glycol)-block-poly(lactide-alt-glycolide)

PEG average Mn 5000, PLGA Mn 15000

Synonym(s):

Drug release, PEG-PLGA with disulfide linkage, PEG-SS-PLGA, Stimuli-responsive

Sign Into View Organizational & Contract Pricing
All Photos(1)

About This Item

Linear Formula:
CH3O(C2H4O)nC7H12O4S2(C5H6O4)m
UNSPSC Code:
12352112
NACRES:
NA.23

form

powder, chunks or granules

Quality Level

100

mol wt

PEG average Mn 5000
PLGA Mn 15000

storage temp.

2-8°C

SMILES string

O=C(C(C)OC(CO[H])=O)OCCSSCCOC(OCCOCCOC)=O

Related Categories

Application

PEG-SS-PLGA is a redox responsive, biocompatible, amphiphilic block copolymer composed of a hydrophilic PEG block and a hydrophobic poly(lactide-alternative-glycolide) (PLGA) block, with a reducible disulfide linkage between blocks. This polymer can be fabricated into Glutathione (GSH) responsive nanoparticles which can be used as an intracellular drug delivery system.

Different from common Poly(lactide-co-glycolide) (PLGA) polymer, the lactic and glycolic units in Poly(lactide-alt-glycolide) block alternate in sequence in the polymer chain, and the molar ratio of lactic to glycolic units in the polymer is exactly 1:1.

Poly(lactide-alt-glycolide) exhibits excellent solubility in common organic solvents, such as acetonitrile, acetone, dioxane, DCM, and THF, providing great convenience for drug delivery researches and applications.

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Claudia Conte et al.
Journal of controlled release : official journal of the Controlled Release Society, 277, 126-141 (2018-03-15)
In the treatment of lung cancer, there is an urgent need of innovative medicines to optimize pharmacological responses of conventional chemotherapeutics while attenuating side effects. Here, we have exploited some relatively unexplored subtle differences in reduction potential, associated with cancer
Lin Yu et al.
Biomacromolecules, 12(4), 1290-1297 (2011-03-03)
This paper reports the influence of sequence structures of block copolymers composed of poly(lactic acid-co-glycolic acid) (PLGA) and poly(ethylene glycol) (PEG) on their thermogelling aqueous behaviors. A series of thermogelling PLGA-PEG-PLGA triblock copolymers with similar chemical compositions and block lengths

Articles

Therapeutic Nanoparticles Harness Myeloid Cells for Brain Tumor-Targeted Delivery and Immunomodulation

Immunosuppressive tumor-associated myeloid cells (TAMC) are responsible for glioblastoma (GBM) resistance to immunotherapies and existing standard of care treatments. This mini-review highlights recent progress in implementing nanotechnology in advancing TAMC-targeted therapies for GBM.

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service