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925624

Sigma-Aldrich

Redox Responsive Poly(ethylene glycol)-block-poly(ε-caprolactone)

PEG average Mn 5,000, PCL Mn 15,000

Synonym(s):

Block copolymer, PEG-PCL with disulfide linkage, PEG-SS-PCL, Stimuli-responsive

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About This Item

Linear Formula:
CH3O(C2H4O)nC7H12O4S2(C6H10O2)
UNSPSC Code:
12352112
NACRES:
NA.23

form

solid (could be powder/granules/chunks)

Quality Level

100

mol wt

PCL Mn 15,000
PEG average Mn 5,000

color

white to beige, light yellow

storage temp.

2-8°C

Related Categories

Application

PEG-SS-PCL is a redox responsive, biocompatible, amphiphilic block copolymer composed of a hydrophilic poly(ethylene glycol) (PEG) block and a hydrophobic poly(ε-caprolactone) (PCL) block, with a reducible disulfide linkage between blocks. This polymer can be fabricated into Glutathione (GSH) responsive nanoparticles which can be used as an intracellular drug delivery system.

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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pH/redox dual-sensitive nanoparticles based on the PCL/PEG triblock copolymer for enhanced intracellular doxorubicin release.
Cao Y, et al.
Royal Society of Chemistry Advances, 5, 28060-28069 (2015)
Philip Grossen et al.
Journal of controlled release : official journal of the Controlled Release Society, 260, 46-60 (2017-05-26)
The lack of efficient therapeutic options for many severe disorders including cancer spurs demand for improved drug delivery technologies. Nanoscale drug delivery systems based on poly(ethylene glycol)-poly(ε-caprolactone) copolymers (PEG-PCL) represent a strategy to implement therapies with enhanced drug accumulation at

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