922307
Poly(lactide-alt-glycolide)
average Mn 10000, lactide:glycolide 50:50
Synonym(s):
PLLA-alt-PGA
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About This Item
Linear Formula:
(C5H6O4)n
UNSPSC Code:
12162002
NACRES:
NA.23
form
powder
Quality Level
feed ratio
lactide:glycolide 50:50
mol wt
average Mn 10000
color
white to beige
storage temp.
2-8°C
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Application
Poly(lactide-alt-glycolide) contains alternating sequence of lactide and clycolide in the polymer chain, unlike Poly(lactide-co-glycolide) (PLGA). The molar ratio of lactic to glycolic units in the polymer is exactly 1:1. Poly(lactide-alt-glycolide) has improved solutibilty in a broad range of organic solvents such as acetonitrile, acetone, dioxane, DCM and THF, providing great convenience for drug delivery researches and applications. Traditional PLGA polymers have a random distribution of glycolide and lactide units which impacts solutibilty. Compared to random PLGA with LA:GA ratios of 50/50, alternative PLGA undergoes hydrolysis in vivo with minimal changes in pH and a lower amount of acidic by-products.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
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Ji Hoon Jeong et al.
Journal of biomaterials science. Polymer edition, 14(1), 1-11 (2003-03-15)
A series of amphipathic graft copolymers composed of poly(L-lysine) (PLL) as the cationic polymer backbone and biodegradable poly(D,L-lactic-co-glycolic acid) (PLGA) as the grafting chains were synthesized and characterized. The terminal group of PLGA was activated and chemically conjugated to the
Michael A Washington et al.
Acta biomaterialia, 65, 259-271 (2017-11-05)
Controlling the backbone architecture of poly(lactic-co-glycolic acid)s (PLGAs) is demonstrated to have a strong influence on the production and release of acidic degradation by-products in microparticle matrices. Previous efforts for controlling the internal and external accumulation of acidity for PLGA
Lin Yu et al.
Biomacromolecules, 12(4), 1290-1297 (2011-03-03)
This paper reports the influence of sequence structures of block copolymers composed of poly(lactic acid-co-glycolic acid) (PLGA) and poly(ethylene glycol) (PEG) on their thermogelling aqueous behaviors. A series of thermogelling PLGA-PEG-PLGA triblock copolymers with similar chemical compositions and block lengths
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