920703
((1-(tert-Butoxycarbonyl)piperidin-4-yl)methyl)proline
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Synonym(s):
Rigid linker for PROTAC® development
Empirical Formula (Hill Notation):
C16H28N2O4
Molecular Weight:
312.40
UNSPSC Code:
12352209
NACRES:
NA.22
Recommended Products
form
powder
Quality Level
reaction suitability
reagent type: linker
functional group
Boc
carboxylic acid
storage temp.
2-8°C
SMILES string
CC(C)(OC(N1CCC(CC1)CN2CCCC2C(O)=O)=O)C
Related Categories
Application
((1-(tert-Butoxycarbonyl)piperidin-4-yl)methyl)proline is useful as a rigid linker in PROTAC development for targeted protein degradation as well as chemical conjugates. Incorporation of rigidity into the linker region of bifunctional protein degraders may impact the 3D orientation of the degrader and thus ternary complex formation as well as optimization of drug-like properties. Developed in partnership with ComInnex.
Similar linkers in this series:
920533
920649
920665
920673
Similar linkers in this series:
920533
920649
920665
920673
Other Notes
Legal Information
PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license
related product
Product No.
Description
Pricing
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
新产品
Certificates of Analysis (COA)
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