920665
2-(1-(1-(tert-Butoxycarbonyl)piperidin-3-yl)-1H-pyrazol-4-yl)acetic acid
Synonym(s):
Rigid linker for PROTAC® development
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About This Item
Empirical Formula (Hill Notation):
C15H23N3O4
CAS Number:
Molecular Weight:
309.36
UNSPSC Code:
12352106
NACRES:
NA.22
reaction suitability
reagent type: linker
Quality Level
functional group
Boc
carboxylic acid
SMILES string
CC(C)(OC(N1CCCC(N2C=C(C=N2)CC(O)=O)C1)=O)C
Related Categories
Application
2-(1-(1-(tert-Butoxycarbonyl)piperidin-3-yl)-1H-pyrazol-4-yl)acetic acid is useful as a rigid linker in PROTAC development for targeted protein degradation as well as chemical conjugates. Incorporation of rigidity into the linker region of bifunctional protein degraders may impact the 3D orientation of the degrader and thus ternary complex formation as well as optimization of drug-like properties. Developed in partnership with ComInnex.
Similar linkers in this series:
920533
920649
920673
920703
Similar linkers in this series:
920533
920649
920673
920703
Other Notes
Legal Information
PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license
Practum is a registered trademark of Sartorius Lab Instruments GmbH & Co. KG
related product
Product No.
Description
Pricing
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
新产品
Certificates of Analysis (COA)
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