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920460

Sigma-Aldrich

GPhos Pd G3

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Empirical Formula (Hill Notation):
C48H66NO5PPdS
CAS Number:
2489525-82-6
Molecular Weight:
906.50
UNSPSC Code:
12352300
NACRES:
NA.22

form

powder

Quality Level

100

reaction suitability

reagent type: catalyst
reaction type: Cross Couplings

mp

>300 °C

SMILES string

O=S(=O)([O-][Pd+2]1([C-]=2C=CC=CC2C=3C=CC=CC3[NH2]1)[P](C=4C(OC(C)(C)C)=CC=C(OC)C4C=5C(=CC=CC5C(C)C)C(C)C)(C6CCCCC6)C7CCCCC7)C

InChI

InChI=1S/C35H53O2P.C12H10N.CH4O3S.Pd/c1-24(2)28-20-15-21-29(25(3)4)32(28)33-30(36-8)22-23-31(37-35(5,6)7)34(33)38(26-16-11-9-12-17-26)27-18-13-10-14-19-27;13-12-9-5-4-8-11(12)10-6-2-1-3-7-10;1-5(2,3)4;/h15,20-27H,9-14,16-19H2,1-8H3;1-6,8-9H,13H2;1H3,(H,2,3,4);/q;-1;;+2/p-1

InChI key

PLMOFCQYSAAMKA-UHFFFAOYSA-M

Related Categories

Application

GPhos Pd G3 is a third generation (G3) Buchwald palladium precatalyst for cross-coupling, demonstrating improved stability and reactivity from previous generations.

Learn more about G3 and G4 Buchwald Precatalysts

Other Notes

Development of an Aryl Amination Catalyst with Broad Scope Guided by Consideration of Catalyst Stability

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Flash Point(F)

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Flash Point(C)

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Certificates of Analysis (COA)

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Scott D McCann et al.
Journal of the American Chemical Society, 142(35), 15027-15037 (2020-08-14)
We have developed a new dialkylbiaryl monophosphine ligand, GPhos, that supports a palladium catalyst capable of promoting carbon-nitrogen cross-coupling reactions between a variety of primary amines and aryl halides; in many cases, these reactions can be carried out at room

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