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Merck
CN

915599

Carboxylic acid-poly(ethylene glycol)-b-poly(ε-caprolactone)

PEG average Mn 2,000, PCL average Mn 5,000

Synonym(s):

Carboxylic acid PEG-PCL diblock copolymer, Carboxylic acid-PEG-PCL, PEG-b-PCL, PEG-PCL

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About This Item

Linear Formula:
C3H5O3[C2H4O]n[C6H10O2]mH
UNSPSC Code:
12352106
NACRES:
NA.23

Key Documents

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Product Name

Carboxylic acid-poly(ethylene glycol)-b-poly(ε-caprolactone), PEG average Mn 2,000, PCL average Mn 5,000

InChI

1S/C11H20O6/c12-6-3-1-2-4-11(15)17-9-8-16-7-5-10(13)14/h12H,1-9H2,(H,13,14)

InChI key

RUCUHLNLCAIHAG-UHFFFAOYSA-N

SMILES string

[H]OCCCCCC(OCCOCCC(O)=O)=O

form

powder or chunks

mol wt

PCL average Mn 5,000 (by NMR)
PCL average Mn 5,000
PEG average Mn 2,000 (by NMR)
PEG average Mn 2,000

color

white to beige

PDI

≤1.3 (by GPC)

storage temp.

−20°C

Quality Level

100

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Application

Carboxylic acid-poly(ethylene glycol)-b-poly(ε-caprolactone) is a functionalized, amphiphilic, diblock copolymer composed of a hydrophilic PEG block and a hydrophobic PCL block. These biodegradable, biocompatible polymers can self-assemble to form nanoparticles, such as micelles and polymersomes, in both aqueous and non-aqueous media. Due to these properties, these polymers are widely used in polymeric nanoparticle formulation to achieve controlled and targeted delivery of therapeutic agents (e.g. APIs, genetic material, peptides, vaccines, and antibiotics). Additionally, well-defined nanoparticles with tunable size and properties can be prepared by altering the molecular weight ratios between hydrophilic and hydrophobic blocks, as well as by controlling formulation parameters. The carboxylic acid functional group on the PEG chain enables rapid and facile surface functionalization, allowing for these materials to be used in applications such as targeted drug delivery.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
MKCM9500

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Jian Jin et al.
PloS one, 9(11), e112200-e112200 (2014-11-12)
In this content, a small molecular ligand of prostate specific membrane antigen (SMLP) conjugated poly (caprolactone) (PCL)-b-poly (ethylene glycol) (PEG) copolymers with different block lengths were synthesized to construct a satisfactory drug delivery system. Four different docetaxel-loaded polymeric micelles (DTX-PMs)
Cem Varan et al.
Beilstein journal of nanotechnology, 8, 1446-1456 (2017-09-14)
Background: Brain tumors are the most common tumors among adolescents. Although some chemotherapeutics are known to be effective against brain tumors based on cell culture studies, the same effect is not observed in clinical trials. For this reason, the development

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