915343
Maleimide-poly(ethylene glycol)-b-poly(ε-caprolactone)
PEG average Mn 5,000, PCL average Mn 10,000
Synonym(s):
Maleimide PEG-PCL diblock copolymer, PEG-b-PCL, PEG-PCL
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About This Item
Linear Formula:
C7H7N2O3[C2H4O]n[C6H10O2]mH
NACRES:
NA.23
UNSPSC Code:
12352111
Product Name
Maleimide-poly(ethylene glycol)-b-poly(ε-caprolactone), PEG average Mn 5,000, PCL average Mn 10,000
form
powder or solid
mol wt
PCL average Mn 10,000 (by NMR)
PCL average Mn 10,000
PEG average Mn 5,000 (by NMR)
PEG average Mn 5,000
color
off-white to yellow
PDI
≤1.4 (by GPC)
storage temp.
−20°C
Quality Level
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Application
Maleimide-poly(ethylene glycol)-b-poly(ε-caprolactone) is a functionalized, amphiphilic, diblock copolymer composed of a hydrophilic PEG block and a hydrophobic PCL block. These biodegradable, biocompatible polymers can self-assemble to form nanoparticles, such as micelles and polymersomes, in both aqueous and non-aqueous media. Due to these properties, these polymers are widely used in polymeric nanoparticle formulation to achieve controlled and targeted delivery of therapeutic agents (e.g. APIs, genetic material, peptides, vaccines, and antibiotics). Additionally, well-defined nanoparticles with tunable size and properties can be prepared by altering the molecular weight ratios between hydrophilic and hydrophobic blocks, as well as by controlling formulation parameters. The carboxylic acid functional group on the PEG chain enables rapid and facile surface functionalization, allowing for these materials to be used in applications such as targeted drug delivery.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Jian Jin et al.
PloS one, 9(11), e112200-e112200 (2014-11-12)
In this content, a small molecular ligand of prostate specific membrane antigen (SMLP) conjugated poly (caprolactone) (PCL)-b-poly (ethylene glycol) (PEG) copolymers with different block lengths were synthesized to construct a satisfactory drug delivery system. Four different docetaxel-loaded polymeric micelles (DTX-PMs)
Cem Varan et al.
Beilstein journal of nanotechnology, 8, 1446-1456 (2017-09-14)
Background: Brain tumors are the most common tumors among adolescents. Although some chemotherapeutics are known to be effective against brain tumors based on cell culture studies, the same effect is not observed in clinical trials. For this reason, the development
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