914258
Carboxylic acid-poly(ethylene glycol)-b-poly(ε-caprolactone)
PEG average Mn 5,000, PCL average Mn 10,000
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Synonym(s):
Carboxylic acid PEG-PCL diblock copolymer, Carboxylic acid-PEG-PCL, PEG-b-PCL, PEG-PCL
Linear Formula:
C3H5O3[C2H4O]n[C6H10O2]mH
UNSPSC Code:
12352106
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form
powder or chunks
Quality Level
mol wt
PCL average Mn 10,000 (by NMR)
PCL average Mn 10,000
PEG average Mn 5,000 (by NMR)
PEG average Mn 5,000
color
white to beige
storage temp.
−20°C
SMILES string
[H]OCCCCCC(OCCOCCC(O)=O)=O
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Application
Carboxylic acid-poly(ethylene glycol)-b-poly(ε-caprolactone) is a functionalized, amphiphilic, diblock copolymer composed of a hydrophilic PEG block and a hydrophobic PCL block. These biodegradable, biocompatible polymers can self-assemble to form nanoparticles, such as micelles and polymersomes, in both aqueous and non-aqueous media. Due to these properties, these polymers are widely used in polymeric nanoparticle formulation to achieve controlled and targeted delivery of therapeutic agents (e.g. APIs, genetic material, peptides, vaccines, and antibiotics). Additionally, well-defined nanoparticles with tunable size and properties can be prepared by altering the molecular weight ratios between hydrophilic and hydrophobic blocks, as well as by controlling formulation parameters. The carboxylic acid functional group on the PEG chain enables rapid and facile surface functionalization, allowing for these materials to be used in applications such as targeted drug delivery.
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
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Jian Jin et al.
PloS one, 9(11), e112200-e112200 (2014-11-12)
In this content, a small molecular ligand of prostate specific membrane antigen (SMLP) conjugated poly (caprolactone) (PCL)-b-poly (ethylene glycol) (PEG) copolymers with different block lengths were synthesized to construct a satisfactory drug delivery system. Four different docetaxel-loaded polymeric micelles (DTX-PMs)
Cem Varan et al.
Beilstein journal of nanotechnology, 8, 1446-1456 (2017-09-14)
Background: Brain tumors are the most common tumors among adolescents. Although some chemotherapeutics are known to be effective against brain tumors based on cell culture studies, the same effect is not observed in clinical trials. For this reason, the development
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