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Key Documents

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912123

Sigma-Aldrich

Trimethyl chitosan

medium molecular weight, degree of quaternization: 40- 60%

Synonym(s):

N,N,N-trimethyl chitosan, Chitosan trimethyl, Mucoadhesive polymers, TMC, TMC Chitosan

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250 REACTIONS
CN¥2,108.32
1250 REACTIONS
CN¥9,461.07

CN¥2,108.32

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250 REACTIONS
CN¥2,108.32
1250 REACTIONS
CN¥9,461.07

About This Item

Linear Formula:
(C9H18ClNO4)n
CAS Number:
52349-26-5
MDL number:
MFCD00008176
UNSPSC Code:
12162002
NACRES:
NA.23

CN¥2,108.32

Please contact Customer Service for Availability
New, lower price on this item!
Request a Bulk Order

Quality Level

100

form

powder

color

light yellow to light brown

storage temp.

2-8°C

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KiCqStart® Probe qPCR ReadyMix™, Low ROX™ with Low ROX for ABI and Stratagene instruments

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KiCqStart® Probe qPCR ReadyMix™, ROX™ with ROX for ABI instruments

KCQS06

KiCqStart® Probe qPCR ReadyMix™, ROX™

KiCqStart® Probe qPCR ReadyMix™ for Bio-Rad, Cepheid, Eppendorf, Illumina, Corbett, and Roche systems

KCQS04

KiCqStart® Probe qPCR ReadyMix™

KiCqStart® One-Step Probe RT-qPCR ReadyMix™, Low ROX™ with Low ROX for ABI and Stratagene instruments

KCQS08

KiCqStart® One-Step Probe RT-qPCR ReadyMix™, Low ROX™

form

liquid

form

liquid

form

liquid

form

liquid

usage

sufficient for 1250 reactions

usage

sufficient for 1250 reactions, sufficient for 250 reactions, sufficient for 5000 reactions

usage

sufficient for 1250 reactions, sufficient for 250 reactions, sufficient for 5000 reactions

usage

sufficient for 500 reactions

feature

dNTPs included

feature

dNTPs included, hotstart

feature

dNTPs included, hotstart

feature

dNTPs included, hotstart

storage condition

protect from light

storage condition

protect from light

storage condition

protect from light

storage condition

protect from light

color

light blue

color

light blue

color

light blue

color

light blue

Application

Chitosan offers remarkable biological properties, it has been widely used in drug delivery and tissue engineering applications. Chitosan has good mucoadhesive properties due to its positive charge, which increases the adhesion to mucosa and facilitates drug penetration. Also, chitosan possesses hemostatic properties, which makes it a good candidate for wound dressing applications.

The quaternization of the primary amine increases the water solubility of chitosan and keeps chitosan soluble over a wide pH range. Among all the quaternized chitosans, N, N, N-trimethyl chitosan chloride (TMC) is the most widely applied in biomedical applications.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

  • Specification Sheet

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    Certificates of Analysis (COA)

    Lot/Batch Number
    MKCM0761

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    Preparation and Characterization of Particles from Chitosan with Different Molecular Weights and Their Trimethyl Chitosan Derivatives for Nasal Immunization.
    BOONYO W, et al.
    Journal of Metals, Materials and Minerals, 18(2), 59-65 (2008)
    Preparation and NMR characterization of highly substituted IV-trimethyl chitosan chloride.
    A B Sieval, et al.
    Carbohydrate Polymers, 36, 157-165 (1998)
    Chitosan and Chitosan Derivatives in Drug Delivery and Tissue Engineering.
    Rieux A D, et al.
    Polymer Science (2011)
    J H Hamman et al.
    Drug development and industrial pharmacy, 29(2), 161-172 (2003-03-22)
    N-trimethyl chitosan chloride (TMC) is a polycation that enhances drug transport across epithelia by opening tight junctions. The degree of quaternization of TMC determines the number of positive charges available on the molecule for interactions with the negatively charged sites
    Amir K Varkouhi et al.
    Bioconjugate chemistry, 21(12), 2339-2346 (2010-11-06)
    N,N,N-Trimethylated chitosan (TMC) is a biodegradable polymer emerging as a promising nonviral vector for nucleic acid and protein delivery. In the present study, we investigated whether the introduction of thiol groups in TMC enhances the extracellular stability of the complexes

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    Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

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