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911321

Sigma-Aldrich

Poly(ethylene glycol) linear dendron

carboxyl terminated, PEG Mn 10,000, generation 2

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Empirical Formula (Hill Notation):
C486H952O249
Molecular Weight:
10780.61
UNSPSC Code:
51171641
NACRES:
NA.25

form

solid

mol wt

PEG Mn 10,000
generation 2

no. Surface Groups

4

color

white to off-white

storage temp.

−20°C

Related Categories

General description

  • Polymer architecture: PEG-linear dendron
  • Generation: 2
  • PEG average Mn: 10,000
  • End Group Functionality: Carboxylic acid
  • No. Surface Groups: 4
  • Calculated Mol. Wt.: 10780.71 g/mol
  • Bis-MPA = 2,2-Bis(hydroxymethyl)propionic acid

Application

Bis-MPA dendritic molecules are based on 2,2-bismethylolpropionicacid (bis-MPA) building blocks. The hydrolyzable linker allows for degradation into byproducts that can be reabsorbed by the body or into excretable non-toxic small molecules. This dendritic polymer is biocompatible, biodegradable, and suitable for biomedical applications. PEG-core dendrons feature excellent solubility in water and a high degree of functionality per PEG chain, enabling use in advanced drug delivery systems or for drug targeting. The carboxylic acid-functionalized corona can be readily used for bioconjugation reactions.

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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Chemistry of multifunctional polymers based on bis-MPA and their cutting-edge applications.
Garcia-Gallego S, et al.
Progress in Polymer Science, 48, 85-110 (2015)
Chemistry of multifunctional polymers based on bis-MPA and their cutting-edge applications.
Garcia-Gallego S, et al
Progress in Polymer Science, 48, 85-110 (2015)
Anna Carlmark et al.
Chemical Society reviews, 42(13), 5858-5879 (2013-05-01)
Dendritic polymers are highly branched, globular architectures with multiple representations of functional groups. These nanoscale organic frameworks continue to fascinate researchers worldwide and are today under intensive investigation in application-driven research. A large number of potential application areas have been

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Dendritic molecules' biomedical applications, particularly bis-MPA dendritic scaffolds, hold promise for drug delivery.

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Dendrimers, polymer nanostructures, are synthesized for specific purposes by manipulating critical nanoscale design parameters (CNDPs).

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