909904
4arm-poly(lactide-co-glycolide)
average Mn 38,000-60,000, lactide:glycolide 55:45
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Synonym(s):
4 arm PLGA, 4 arm-PLGA, 4arm-PLGA
Linear Formula:
C5H8O4((((C3H4O2)x(C2H2O2)y)m)H)4
UNSPSC Code:
12162002
NACRES:
NA.23
Recommended Products
form
powder or chunks
feed ratio
lactide:glycolide 55:45
mol wt
average Mn 38,000-60,000
color
white to tan
storage temp.
−20°C
Related Categories
Application
Biocompatible and biodegradable polymer. Can be used in the formation of nanoparticles for drug delivery. The multi-arm molecular structure might promote high drug loading, superior colloidal stability, as well as long circulation time.
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
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Xiuxiu Wang et al.
Biomacromolecules, 19(4), 1368-1373 (2018-03-20)
PLGA, a copolymer of lactide and glycolide, is one of the most used biodegradable polymers that find a wide range of biomedical applications including drug delivery and tissue engineering. However, in spite of remarkable advancement, nanotherapeutics based on PLGA might
R Gref et al.
Science (New York, N.Y.), 263(5153), 1600-1603 (1994-03-18)
Injectable nanoparticulate carriers have important potential applications such as site-specific drug delivery or medical imaging. Conventional carriers, however, cannot generally be used because they are eliminated by the reticulo-endothelial system within seconds or minutes after intravenous injection. To address these
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Professor Robert K. Prud’homme introduces flash nanoprecipitation (FNP) for nanoparticle fabrication, which is a scalable, rapid mixing process for nanoparticle formulations.
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