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Merck
CN

909149

Poly(ethylene glycol) diamine

average Mn 400

Synonym(s):

Poly(ethylene glycol) bis(amine), Polyethylene glycol, O,O′-Bis(2-aminoethyl)polyethylene glycol, Diaminopolyethylene glycol, PEG-diamine, Polyoxyethylene bis(amine)

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About This Item

Linear Formula:
H2N(CH2CH2O)nCH2CH2NH2
CAS Number:
24991-53-5
UNSPSC Code:
43211915
NACRES:
NA.23
MDL number:
MFCD00132004

Key Documents

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Product Name

Poly(ethylene glycol) diamine, average Mn 400

SMILES string

NCCOCCOCCN

InChI

1S/C6H16N2O2/c7-1-3-9-5-6-10-4-2-8/h1-8H2

InChI key

IWBOPFCKHIJFMS-UHFFFAOYSA-N

form

viscous liquid

mol wt

average Mn 400 (by NMR)
average Mn 400

reaction suitability

reagent type: cross-linking reagent
reactivity: carboxyl reactive

color

colorless to pale yellow

Ω-end

amine

α-end

amine

polymer architecture

shape: linear
functionality: homobifunctional

storage temp.

2-8°C

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Application

PEGylated materials have found broad use in drug delivery systems, virology, and immunology, as the incorporation of PEG improves pharmacological properties such as increased water solubility, enhanced resistance to degradation (protein hydrolysis), increased circulation half-life, and reduced antigenicity. Polymer for preparing enzyme conjugates soluble in organic solvents; promising drug carrier.

Storage Class

10 - Combustible liquids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
MKCT0872
MKCS2410
MKCL5203

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Attaching folic acid on gold nanoparticles using noncovalent interaction via different polyethylene glycol backbones and targeting of cancer cells.
Bhattacharya R, et al.
Nanomedicine: Nanotechnology, Biology, and Medicine, 3, 224-238 (2007)
Facile Synthesis of a Degradable Poly(ethylene glycol) Platform with Tunable Acid Sensitivity at Physiologically Relevant pH.
Li Z C, et al.
Macromolecules, 51, 6571-6579 (2018)
Rigidity of Two-Component Hydrogels Prepared from Alginate and Poly(ethylene glycol)-Diamines.
Eiselt P, et al.
Macromolecules, 32 (17), 5561-5566 (1999)

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