909076
Poly(lactide-co-glycolide)-b-poly(ethylene glycol)-b-poly(lactide-co-glycolide)
average Mn (1,700-1,500-1,700), lactide:glycolide (95:5)
Synonym(s):
PLGA-PEG-PLGA
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About This Item
Linear Formula:
H((C3H4O2)x(C2H2O2)y)m((C2H4O)z)nO((C3H4O2)x(C2H2O2)y)mH
UNSPSC Code:
51171641
NACRES:
NA.23
form
semisolid
feed ratio
lactide:glycolide (95:5)
mol wt
PEG average Mn 1,500 (by NMR)
PLGA average Mn 3,400 (by NMR)
average Mn (1,700-1,500-1,700)
color
white to tan
PDI
≤2.0
<1.1 (Typical PEG PDI )
storage temp.
−20°C
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Application
PLGA-PEG-PLGA is an amphiphilic triblock copolymer which can self-assemble into micelles in aqueous medium due to the hydrophobic interactions present in the hydrophobic segments. The PEG segment imparts hydrophilicity and improves the biocompatibility of the copolymer. The PLGA segment forms a hydrophobic core and can solubilize hydrophobic drugs. These copolymers are widely used as nanocarriers for the sustained release of drugs. Also this polymer exhibits thermogelation behavior. When applied in biomedical applications, the temperature responsive nature of the copolymer can be tuned to induce an in situ gelation at physiological temperature to provide controlled drug release. These materials have been explored for biomedical applications as temperature-responsive biodegradable systems for drug delivery, tissue engineering and wound healing.
WGK
nwg
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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Byeongmoon Jeong et al.
Biomacromolecules, 3(4), 865-868 (2002-07-09)
This paper reports on the thermogelling, biodegradable polymer formulations based on poly(DL-lactic acid-co-glycolic acid)/(poly(ethylene glycol) graft copolymers for in vivo biomedical applications using animal models. The description includes diabetic control by sustained insulin delivery and cartilage repair by chondrocyte cell
Thermoreversible Gelation of PEG-PLGA-PEG Triblock Copolymer Aqueous Solutions.
Jeong B, et al.
Macromolecules, 32(21), 7064-7069 (1999)
Chayanin Pratoomsoot et al.
Biomaterials, 29(3), 272-281 (2007-11-03)
Ocular trauma and disorders that lead to corneal blindness account for over 2 million new cases of monocular blindness every year. A popular ocular surface reconstruction therapy, amniotic membrane transplantation, has been shown to aid corneal wound repair. However, the
Mingxi Qiao et al.
Die Pharmazie, 61(3), 199-202 (2006-04-08)
Biodegradable thermosensitive poly (DL-lactide-co-glycolide-b-ethylene glycol-b-DL-lactide-co-glycolide) (PLGA-PEG-PLGA) triblock copolymers with DL-lactide/glycolide molar ratio ranging from 6/1 to 15/1 were synthesized from monomers of DL-lactide, glycolide and polyethylene glycol and were evaluated for sustained release of bee venom peptide in vitro. The
Jun Ge et al.
ACS nano, 6(1), 227-233 (2011-11-25)
We describe a new temperature and electric field dual-stimulus responsive nanoparticle system for programmed drug delivery. Nanoparticles of a conducting polymer (polypyrrole) are loaded with therapeutic pharmaceuticals and are subcutaneously localized in vivo with the assistance of a temperature-sensitive hydrogel
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