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901575

Sigma-Aldrich

t-Boc-N-amido-PEG3-CH2CO2H

≥95%

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About This Item

Empirical Formula (Hill Notation):
C13H25NO7
CAS Number:
Molecular Weight:
307.34
MDL number:
UNSPSC Code:
51171641
NACRES:
NA.22

Assay

≥95%

form

liquid

reaction suitability

reagent type: linker

functional group

Boc
amine
carboxylic acid

storage temp.

−20°C

SMILES string

OC(COCCOCCOCCNC(OC(C)(C)C)=O)=O

InChI

1S/C13H25NO7/c1-13(2,3)21-12(17)10(14)8-19-6-4-18-5-7-20-9-11(15)16/h10H,4-9,14H2,1-3H3,(H,15,16)

InChI key

FUUVHHQEYXVKFA-UHFFFAOYSA-N

Application

This is a crosslinker with a t-Boc protected amine on one end and a carboxyl group on the other end. The compound contains three PEG units to help improve solubility.
t-Boc-N-amido-PEG3-CH2CO2H is a heterobifunctional, PEGylated crosslinker featuring a Boc-protected amine at one end and a carboxyl group at the other. The hydrophillic PEG linker facilitates solubility in biological applications. t-Boc-N-amido-PEG3-CH2CO2H can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC® molecules) for targeted protein degradation.

Legal Information

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

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Regulatory Information

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