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901568

Sigma-Aldrich

Bromo-PEG3-acid

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Empirical Formula (Hill Notation):
C9H17BrO5
CAS Number:
Molecular Weight:
285.13
MDL number:
UNSPSC Code:
12352101
NACRES:
NA.22

form

liquid

reaction suitability

reagent type: linker

functional group

bromo
carboxylic acid

storage temp.

−20°C

SMILES string

BrCCOCCOCCOCCC(O)=O

Application

Bromo-PEG3-acid is a heterobifunctional, PEGylated crosslinker featuring a bromo group at one end and a carboxyl group at the other. The hydrophillic PEG linker facilitates solubility in biological applications. Bromo-PEG3-acid can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC® molecules) for targeted protein degradation.
This is a crosslinker with a bromo group on one end and a carboxyl group on the other end. The compound contains three PEG units to help improve solubility.

Legal Information

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

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