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Safety Information

901553

Sigma-Aldrich

Allyl-modified gelatin

gel strength 300 g Bloom, Degree of substitution: 70% by TNBS method

Synonym(s):

Gelatin-ene, Pentenoyl gelatin

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About This Item

UNSPSC Code:
12352202
NACRES:
NA.23

form

powder

color

white to pale yellow

suitability

conforms to structure for NMR

storage temp.

2-8°C

Application

Allyl-modified gelatin can be used in the synthesis of synthetic hydrogels, which can be potentially used in applications such as drug delivery and biosensors.
Gelatin has received significant attention in the biomedical field due to its inherent bioactivity. Functionalized gelatin can be crosslinked with the formation of covalent bonds into highly crosslinked structures, such as hydrogels. Recent literature suggests that radical-mediated polymerized hydrogels may not be ideal for cell and protein encapsulation due to radical-mediated damage, hindered molecular transport, or altered cell–cell/cell–material interactions. Allyl-modified gelatin can be used to form hydrogels with multifunctional thiol crosslinkers via thiol–ene click or Michael-addition reactions.

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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Monatshefte fur Chemie / Chemical Monthly null
Gelatin hydrogels via thiol-ene chemistry.
Russo L, et al.
Monatshefte fur Chemie / Chemical Monthly, 147, 587-592 (2016)
Kedi Xu et al.
Acta biomaterialia, 9(11), 8802-8814 (2013-07-03)
Mesenchymal stromal/stem cells (MSCs) are considered promising cellular therapeutics in the fields of tissue engineering and regenerative medicine. MSCs secrete high concentrations of immunomodulatory cytokines and growth factors, which exert paracrine effects on infiltrating immune and resident cells in the
Gelatin hydrogels via thiol-ene chemistry
Russo L, et al.
Monatshefte fur Chemie / Chemical Monthly, 147(3), 587-592 (2016)

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