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Key Documents

Safety Information

901417

Sigma-Aldrich

N-((1S,2S)-1-((R)-4-Isobutyl-4,5-dihydrooxazol-2-yl)-2-methylbutyl)acetamide

Synonym(s):

Chiral APAO ligand

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About This Item

Empirical Formula (Hill Notation):
C14H26N2O2
CAS Number:
Molecular Weight:
254.37
UNSPSC Code:
12352202

form

powder or crystals

reaction suitability

reagent type: catalyst
reagent type: ligand
reaction type: C-H Activation

storage temp.

−20°C

Application

Chiral bidentate ligand developed by Jin-Quan Yu.′s lab for enantioselective borylation of C(sp3)–H bonds. This acetyl-protected aminomethyl oxazoline (APAO) ligand was demonstrated to be compatible with carbocyclic substrates with both α-tertiary and α-quaternary carbon centres.

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Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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Jian He et al.
Journal of the American Chemical Society, 139(9), 3344-3347 (2017-02-18)
Pd(II)-catalyzed enantioselective borylation of C(sp

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