901374
Polyester bis-MPA dendron
no. Surface Groups 4, acetylene, 1 NHBoc (core), generation 2
Synonym(s):
Bis-MPA dendron, PFd-G2-BOCNH-Acetylene
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About This Item
Empirical Formula (Hill Notation):
C59H79NO29
Molecular Weight:
1266.25
NACRES:
NA.23
UNSPSC Code:
12162002
form
solid
mol wt
generation 2
no. Surface Groups
4
color
white to off-white
storage temp.
−20°C
General description
- Polymer architecture: Dendron
- Generation: 2
- Core functional group: Boc-protected amine
- End Group Functionality: Alkyne
- No. Surface Groups: 4
- Calculated Mol. Wt.: 1266.26 g/mol
- Boc : tert-Butyloxycarbonyl
- Bis-MPA : 2,2-Bis(hydroxymethyl)propionic acid
Application
Bis-MPA (or 2,2-Bis(methylol)propionic acid) is an aliphatic, pro-chiral molecule comprised of two hydroxyls and one carboxylic group that has been used in the synthesis of many different types of polymers. Dendrons synthesized from Bis-MPA are biodegradable and have low cytotoxicity, making them well suited for use in biological research applications. These materials have been used in many applications such as signal amplification in bioassays and in drug delivery applications. These alkyne-functionalized dendrimers can be readily functionalized using either copper(I)-catalysed alkyne-azide cycloaddition (CuAAC), strain-promoted alkyne-azide cycloaddition (SPAAC), or thiol-yne click reactions. Additionally, the amine-functionalized core can be readily used in EDC or DCC coupling reactions (after Boc deprotection) with carbonyl-containing compounds to yield highly functionalized materials for a variety of biomedical applications.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Anna Carlmark et al.
Chemical Society reviews, 42(13), 5858-5879 (2013-05-01)
Dendritic polymers are highly branched, globular architectures with multiple representations of functional groups. These nanoscale organic frameworks continue to fascinate researchers worldwide and are today under intensive investigation in application-driven research. A large number of potential application areas have been
Articles
Dendritic molecules' biomedical applications, particularly bis-MPA dendritic scaffolds, hold promise for drug delivery.
Dendrimers, polymer nanostructures, are synthesized for specific purposes by manipulating critical nanoscale design parameters (CNDPs).
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