901315
Polyester bis-MPA dendron 8 NHBoc, 1 acetylene (core)
generation 3
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Synonym(s):
Bis-MPA dendron, PFd-G3-Acetylene-NH-BOC
Empirical Formula (Hill Notation):
C102H164N8O46
Molecular Weight:
2238.42
UNSPSC Code:
12352200
NACRES:
NA.23
Recommended Products
form
crystals
mol wt
generation 3
no. Surface Groups
8
functional group
(Alkyne(core))
storage temp.
−20°C
General description
- Polymer architecture: Dendron
- End Group Functionality: Boc-protected amine
- Boc : tert-Butyloxycarbonyl
- Bis-MPA : 2,2-Bis(hydroxymethyl)propionic acid
Application
Bis-MPA (or 2,2-Bis(methylol)propionic acid) is an aliphatic, pro-chiral molecule comprised of two hydroxyls and one carboxylic group that has been used in the synthesis of many different types of polymers. Dendrons synthesized from bis-MPA are biodegradable and have low cytotoxicity, making them well suited for use in biological research applications. These materials have been used in many applications such as signal amplification in bioassays and in drug delivery applications. After Boc deprotection, amine-functionalized dendrons can be readily used in EDC or DCC coupling reactions with carbonyl-containing compounds to yield highly functionalized materials for a variety of biomedical applications. Additionally, the alkyne-core can be readily conjugates using either copper(I)-catalyzed alkyne-azide cycloaddition (CuAAC) or strain-promoted alkyne-azide cycloaddition (SPAAC).
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
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Anna Carlmark et al.
Chemical Society reviews, 42(13), 5858-5879 (2013-05-01)
Dendritic polymers are highly branched, globular architectures with multiple representations of functional groups. These nanoscale organic frameworks continue to fascinate researchers worldwide and are today under intensive investigation in application-driven research. A large number of potential application areas have been
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