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901312

Sigma-Aldrich

Polyester bis-MPA dendron 4 NHBoc, 1 thiol (core)

generation 2

Synonym(s):

Bis-MPA dendron, PFd-G2-Thiol-NH-BOC

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About This Item

Empirical Formula (Hill Notation):
C49H82N4O22S
Molecular Weight:
1111.25
UNSPSC Code:
12352105
NACRES:
NA.23

description

4 NHBoc, 1 thiol (core)

form

solid

mol wt

generation 2

no. Surface Groups

4

color

white to off-white

functional group

thiol (core)

storage temp.

−20°C

General description

  • Polymer architecture: Dendron
  • End Group Functionality: Boc-protected amine
  • Boc: tert-Butyloxycarbonyl
  • Bis-MPA : 2,2-Bis(hydroxymethyl)propionic acid.

Application

Bis-MPA (or 2,2-Bis(methylol)propionic acid) is an aliphatic, pro-chiral molecule comprised of two hydroxyls and one carboxylic group that has been used in the synthesis of many different types of polymers. Dendrons synthesized from bis-MPA are biodegradable and have low cytotoxicity, making them well suited for use in biological research applications. These materials have been used in many applications such as signal amplification in bioassays and in drug delivery applications. After Boc deprotection, amine-functionalized dendrons can be readily used in EDC or DCC coupling reactions with carbonyl-containing compounds to yield highly functionalized materials for a variety of biomedical applications. Additionally, the thiol-core can be readily conjugated via a thiol-ene click reaction, Michael addition reactions, or disulfide exchange.

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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Anna Carlmark et al.
Chemical Society reviews, 42(13), 5858-5879 (2013-05-01)
Dendritic polymers are highly branched, globular architectures with multiple representations of functional groups. These nanoscale organic frameworks continue to fascinate researchers worldwide and are today under intensive investigation in application-driven research. A large number of potential application areas have been

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