900948
Poly(ethylene glycol) methyl ether-block-poly(lactide-co-glycolide)
PEG average Mn 5,000, PLGA Mn 15,000, lactide:glycolide 50:50
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Synonym(s):
PEG-PLGA, Polyethylene glycol, mPEG-b-PLGA
Linear Formula:
H[(C3H4O2)x(C2H2O2)y]mO[C2H4O]nCH3
UNSPSC Code:
12352200
NACRES:
NA.23
Recommended Products
form
crystals
Quality Level
feed ratio
lactide:glycolide 50:50
mol wt
PEG average Mn 5,000
PLGA Mn 15,000
impurities
≤5000 ppm (GC)
storage temp.
−20°C
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General description
Contains ≤500 ppm impurities by GC, including trace monomer and residual organics.
Application
Biocompatible block copolymer. Can be used in the formation of nanoparticles for drug delivery. Potenial use in the targeted and/or controlled release of cancer drugs, anti-inflammatory drugs, antibiotics, or anesthetic agents.
WGK
WGK 3
Flash Point(F)
>230.9 °F
Flash Point(C)
> 110.5 °C
Regulatory Information
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Miles A Miller et al.
Nature communications, 6, 8692-8692 (2015-10-28)
Therapeutic nanoparticles (TNPs) aim to deliver drugs more safely and effectively to cancers, yet clinical results have been unpredictable owing to limited in vivo understanding. Here we use single-cell imaging of intratumoral TNP pharmacokinetics and pharmacodynamics to better comprehend their
Yihan Xu et al.
Journal of biomedical materials research. Part B, Applied biomaterials, 105(6), 1692-1716 (2016-04-22)
Poly (lactic-co-glycolic acid) (PLGA) copolymers have been broadly used in controlled drug release applications. Because these polymers are biodegradable, they provide an attractive option for drug delivery vehicles. There are a variety of material, processing, and physiological factors that impact
R Gref et al.
Science (New York, N.Y.), 263(5153), 1600-1603 (1994-03-18)
Injectable nanoparticulate carriers have important potential applications such as site-specific drug delivery or medical imaging. Conventional carriers, however, cannot generally be used because they are eliminated by the reticulo-endothelial system within seconds or minutes after intravenous injection. To address these
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