900921
Poly(ethylene glycol) methyl ether-block-poly(lactide-co-glycolide)
PEG average Mn 2,000, PLGA Mn 3,000, lactide:glycolide 50:50
Synonym(s):
PEG-PLGA, Polyethylene glycol, mPEG-b-PLGA
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About This Item
Linear Formula:
H[(C3H4O2)x(C2H2O2)y]mO[C2H4O]nCH3
UNSPSC Code:
51171641
NACRES:
NA.23
form
crystals
Quality Level
feed ratio
lactide:glycolide 50:50
mol wt
PEG average Mn 2,000
PLGA Mn 3,000
impurities
≤5000 ppm (residual monomer by GC)
shipped in
dry ice
storage temp.
−20°C
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Application
Biocompatible block copolymer can be used in the formation of nanoparticles for drug delivery. Potential use in the targeted and/or controlled release of cancer drugs, anti-inflammatory drugs, antibiotics, or anesthetic agents.
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
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Fabienne Danhier et al.
Journal of controlled release : official journal of the Controlled Release Society, 133(1), 11-17 (2008-10-28)
The purpose of this study was to develop Cremophor EL-free nanoparticles loaded with Paclitaxel (PTX), intended to be intravenously administered, able to improve the therapeutic index of the drug and devoid of the adverse effects of Cremophor EL. PTX-loaded PEGylated
Yihan Xu et al.
Journal of biomedical materials research. Part B, Applied biomaterials, 105(6), 1692-1716 (2016-04-22)
Poly (lactic-co-glycolic acid) (PLGA) copolymers have been broadly used in controlled drug release applications. Because these polymers are biodegradable, they provide an attractive option for drug delivery vehicles. There are a variety of material, processing, and physiological factors that impact
R Gref et al.
Science (New York, N.Y.), 263(5153), 1600-1603 (1994-03-18)
Injectable nanoparticulate carriers have important potential applications such as site-specific drug delivery or medical imaging. Conventional carriers, however, cannot generally be used because they are eliminated by the reticulo-endothelial system within seconds or minutes after intravenous injection. To address these
Miles A Miller et al.
Nature communications, 6, 8692-8692 (2015-10-28)
Therapeutic nanoparticles (TNPs) aim to deliver drugs more safely and effectively to cancers, yet clinical results have been unpredictable owing to limited in vivo understanding. Here we use single-cell imaging of intratumoral TNP pharmacokinetics and pharmacodynamics to better comprehend their
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