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About This Item
Empirical Formula (Hill Notation):
C24H31N5O9
CAS Number:
Molecular Weight:
533.53
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.22
Recommended Products
Assay
≥95%
form
powder or crystals
reaction suitability
reaction type: click chemistry
reagent type: cross-linking reagent
functional group
NHS ester
storage temp.
−20°C
SMILES string
CC1=NN=C(N=N1)C2=CC=C(C=C2)OCCOCCOCCOCCOCCC(ON3C(CCC3=O)=O)=O
Application
Methyltetrazine-PEG4-NHS ester is a crosslinker with enhanced stability and water solubility. This crosslinker has an NHS ester that can be reacted with a primary amine and a methyltetrazine that is reactive with trans-cyclooctenes. Methyltetrazine-PEG4-NHS ester is one of the most stable tetrazines commercially available. In addition to stabilization provided by the electron donating methyl group, the electron donating alkoxy substituent on the aromatic ring further improves the stability of methyltetrazine-PEG4-NHS ester. The aqueous solubility of this reagent is substantially enhanced by a hydrophilic polyethylene glycol (PEG) spacer arm.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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Biodegradable tetra-PEG hydrogels as carriers for a releasable drug delivery system.
Henise J, et al.
Bioconjugate Chemistry, 26(2), 270-278 (2015)
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