Recommended Products
form
powder or crystals
availability
available only in USA
mp
162 °C
storage temp.
−20°C
SMILES string
O=C(O[H])[C@@](C([H])([H])C([H])([H])C#C[H])([H])N([H])[H].Cl[H]
InChI
1S/C6H9NO2/c1-2-3-4-5(7)6(8)9/h1,5H,3-4,7H2,(H,8,9)
InChI key
SCGJGNWMYSYORS-UHFFFAOYSA-N
Application
L-Homopropargylglycine (HPG) is an amino acid analog of methionine that contains a very small modification, specifically an alkyne moiety. This compound can be fed to cultured cells and incorporated into proteins during active protein synthesis. Detection utilizes the chemoselective ligation or “click” reaction between an azide and an alkyne or cyclooctyne. For example the alkyne-modified protein can be detected with either fluorescent azide or biotin azide. Detection sensitivity with these reagents in 1-D gels and Western blots is in the low femtomole range and compatible with downstream LC-MS/MS and MALDI-MS analysis.
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Self-react. C
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Find documentation for the products that you have recently purchased in the Document Library.
Cell-free production of Gaussia princeps luciferase?antibody fragment bioconjugates for ex vivo detection of tumor cells.
Patel K G, et al.
Biochemical and Biophysical Research Communications, 390(3), 971-976 (2009)
Cleavable biotin probes for labeling of biomolecules via azide? alkyne cycloaddition.
Szychowski J, et al.
Journal of the American Chemical Society, 132(51), 18351-18360 (2010)
Sirtuin 7 plays a role in ribosome biogenesis and protein synthesis
Tsai Y C, et al.
Molecular and Cellular Proteomics, 13(1), 73-83 (2014)
The dynamic shuttling of SIRT1 between cytoplasm and nuclei in bronchial epithelial cells by single and repeated cigarette smoke exposure.
Yanagisawa S, et al.
PLoS ONE, 13(3), e0193921-e0193921 (2018)
Live-cell imaging of alkyne-tagged small biomolecules by stimulated Raman scattering.
Wei L, et al.
Nature Methods, 11(4), 410-410 (2014)
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