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Safety Information

900790

Sigma-Aldrich

Sodium 5-methylpyridine-2-sulfinate

≥95%

Synonym(s):

Willis 2-pyridylsulfinates para-Me

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About This Item

Empirical Formula (Hill Notation):
C6H6NNaO2S
Molecular Weight:
179.17
UNSPSC Code:
12352200
NACRES:
NA.22

Assay

≥95%

form

powder or crystals

reaction suitability

reaction type: C-C Bond Formation

Application

This 2-pyridylsulfinate enables Suzuki-Miyaura cross coupling with aryl halides to access diverse pyridine derivatives as reported by the laboratory of Michael Willis.. No longer impeded by unstable 2-pyridyl boronates, the sulfinate alternatives provide Pd-catalyzed coupling routes to therapeutically valuable pyridine rings.

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

新产品

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Articles

Description: Professor Willis and partners at Pfizer have shown with pyridine-2- sulfinates a palladium-catalyzed desulfinylative cross-coupling process can be realized.

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Research in the Willis group is focused on the development of new catalysts and reactions for synthetic chemistry. The group is particularly interested in addressing synthetic challenges that are applicable to the pharmaceutical and agrochemical industries.

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