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900762

Sigma-Aldrich

Sodium 4-(trifluoromethyl)pyridine-2-sulfinate

≥95%

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Synonym(s):
Willis 4-trifluoromethyl pyridine 2-sulfinate
Empirical Formula (Hill Notation):
C6H3F3NNaO2S
Molecular Weight:
233.14
UNSPSC Code:
12352200

Assay

≥95%

form

powder or crystals

reaction suitability

reaction type: C-C Bond Formation

Application

This 2-pyridylsulfinate enables Suzuki-Miyaura cross coupling with aryl halides to access diverse pyridine derivatives as reported by the laboratory of Michael Willis.. No longer impeded by unstable 2-pyridyl boronates, the sulfinate alternatives provide Pd-catalyzed coupling routes to therapeutically valuable pyridine rings.

Other Notes

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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Articles

Willis Pyridinates for Palladium-Catalyzed Cross-Coupling Reactions

Description: Professor Willis and partners at Pfizer have shown with pyridine-2- sulfinates a palladium-catalyzed desulfinylative cross-coupling process can be realized.

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