900660
Poly(D,L-lactide)-b-poly(ethylene glycol)-b-poly(D,L-lactide)
5k-2k-5k
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Synonym(s):
PLA-PEG-PLA, PLA-PEG-PLA triblock copolymer
Linear Formula:
HO(CH(CH3)COO)m(CH2CH2O)n(COCH(CH3)O)mH
UNSPSC Code:
12162002
Recommended Products
form
solid
storage temp.
2-8°C
Application
Biocompatible, amphiphilic triblock polymer composed of a hydrophilic, central PEG block and two terminal hydrophobic poly(D,L-lactide) (PLA) blocks. These materials have been used in controlled release formulation and nanoparticle formation for drug delivery applications. Well-defined materials with varying properties can be prepared by controlling the relative length of each polymer block. Hydroxyl termination allows for facile further chemical modification of these materials.
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
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H Danafar et al.
Pharmaceutical development and technology, 22(8), 947-957 (2016-01-08)
A conjugate of the antihypertensive drug, lisinopril, with triblock poly(lactic acid)-poly(ethylene glycol)-poly(lactic acid) (PLA-PEG-PLA) copolymer was synthesized by the reaction of PLA-PEG-PLA copolymer with lisinopril in the presence of dicyclohexylcarbodiimide and dimethylaminopyridine. The conjugated copolymer was characterized in vitro by
Mesoscale simulation and experimental studies of self-assembly behavior of a PLA-PEG-PLA triblock copolymer micelle for sustained drug delivery.
Chansuna M, et al.
Journal of Polymer Research, 21(6), 452-452 (2014)
Kun Shi et al.
Scientific reports, 6, 19077-19077 (2016-01-12)
In this study, a series of injectable thermoreversible and thermogelling PDLLA-PEG-PDLLA copolymers were developed and a systematic evaluation of the thermogelling system both in vitro and in vivo was performed. The aqueous PDLLA-PEG-PDLLA solutions above a critical gel concentration could
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