900339
Poly(lactide-co-glycolide)-b-poly(ethylene glycol)-maleimide
lactide:glycolide 50:50, PEG average Mn 5000, PLGA average Mn 20,000
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Synonym(s):
PLGA-PEG-MAL
Linear Formula:
C9H11N2O3(C2H4O)x(C3H4O2)y(C2H2O2)zH
UNSPSC Code:
12352200
NACRES:
NA.23
Recommended Products
form
chunks
Quality Level
mol wt
PEG average Mn 5000
PLGA average Mn 20,000
composition
lactide:glycolide 50:50
storage temp.
−20°C
Application
Diblock polymer can form micelles by emulsion techniques or microfluidic methods. The maleimide functional group may be used for conjugation to specific binding ligands via thiol-maleimide reaction.
Other Notes
Chapter 5: “Nanobody-Targeted and RNase-Loaded Nanoparticles Based on a Hydrophilic Polyester Aimed for Cancer Therapy” in Samadi, N.
Biodegradable Nanoparticles Based on Aliphatic Polyesters, Towards Targeted Intracellular Delivery of Protein Therapeutics. Ph.D. Thesis, Utrecht University, Utrecht, Netherlands. 2014.
Biodegradable Nanoparticles Based on Aliphatic Polyesters, Towards Targeted Intracellular Delivery of Protein Therapeutics. Ph.D. Thesis, Utrecht University, Utrecht, Netherlands. 2014.
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
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International Journal of Pharmaceutics, 156(1), 9-15 (1997)
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